Results 101 to 110 of about 409,331 (346)

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor

, 2022
Josephine K. Dermawan, Chad Vanderbilt, Jason C. Chang, Brian R. Untch, Samuel Singer, Ping Chi, William D. Tap, Cristina R. Antonescu   +7 more
openalex   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

Supplementary Figure 2 from Stromal EGF and IGF-I Together Modulate Plasticity of Disseminated Triple-Negative Breast Tumors

, 2023
Zafira Castaño, Timothy Marsh, Ramya Tadipatri, Hanna S. Kuznetsov, Fátima Al‐Shahrour, Mahnaz Paktinat, April Greene-Colozzi, Björn Nilsson, Andrea L. Richardson, Sandra S. McAllister   +9 more
openalex   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

TUMOR ESTROMAL GASTROINTESTINAL (GIST): FORMAS DE PRESENTACION

Revista Chilena de Radiología
El tumor estromal gastrointestinal (GIST) representa menos del 3 % de las neoplasias gastrointestinales; sin embargo, es el tumor mesenquimatico mas frecuente del tracto digestivo.
Roberto Oyanedel Q, Andrés O'Brien S, Alejandra Pizarro G, Elizabeth Zamora E, Christine Menias O   +4 more
doaj   +1 more source

Correlation Between Estrogen Receptor Alpha and Progesterone Receptor Expression in Stromal Tissue and Tumor Size of Archived Fibroadenoma Mammae Specimens [PDF]

BIO Web of Conferences
Fibroadenoma of the Breast (FAM) is a benign fibroepithelial breast tumor influenced by estrogen and progesterone through their binding to Estrogen Receptor-a (ER-a) and Progesterone Receptor (PR).
Isdiawan Kemala Anita, Rosidah Aris, Damayanti Dini Sri   +2 more
doaj   +1 more source

A 3D Biofabricated Disease Model Mimicking the Brain Extracellular Matrix Suitable to Characterize Intrinsic Neuronal Network Alterations in the Presence of a Breast Tumor Disseminated to the Brain

Advanced Functional Materials, EarlyView.
A 3D disease model is developed using customized hyaluronic‐acid‐based hydrogels supplemented with extracellular matrix (ECM) proteins resembling brain ECM properties. Neurons, astrocytes, and tumor cells are used to mimic the native brain surrounding.
Esra Türker, Mateo S. Andrade Mier, Jessica Faber, Mike Friedrich, Zan Lamberger, Jeannette Weigelt, Christian Stigloher, Nicoletta Murenu, Natascha Schaefer, Jörg Tessmar, Gregor Lang, Silvia Budday, Katrin G. Heinze, Antje Appelt‐Menzel, Pamela L. Strissel, Reiner Strick, Carmen Villmann   +16 more
wiley   +1 more source

Prostate Stromal Tumor of Uncertain Malignant Potential: Case Report With 5-Year Follow-up

Urology Case Reports, 2014
Prostate stromal tumor of uncertain malignant potential is a term used to describe a specialized proliferation of stromal cells within the prostate. Most of these tumors tend to be benign, but some can present with local invasion or progress to prostatic
Abdo E. Kabarriti, Thomas J. Guzzo, Alan J. Wein   +2 more
doaj   +1 more source