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Gastrointestinal stromal tumor
Surgical Oncology, 2008Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. These form a distinct category of tumors characterized by oncogenic mutations of the KIT receptor tyrosine kinase in a majority of patients. KIT is used not only for diagnosis but also for targeted therapy of GISTs.
Puneet, Gupta +2 more
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The American Surgeon, 2000
Gastric stromal tumors display a bewildering array of immunohistological and ultrastructural features as well as variable biological behavior. These tumors are rare as compared with ones that arise from the gastric epithelium. Moreover, they have been the subjects of controversy because of their uncertain histogenesis.
V S, Parithivel +7 more
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Gastric stromal tumors display a bewildering array of immunohistological and ultrastructural features as well as variable biological behavior. These tumors are rare as compared with ones that arise from the gastric epithelium. Moreover, they have been the subjects of controversy because of their uncertain histogenesis.
V S, Parithivel +7 more
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Gastrointestinal stromal tumors
Virchows Archiv, 2010Gastrointestinal stromal tumors (GISTs) have emerged from being poorly defined, treatment-resistant tumors to a well-recognized, well-understood, and treatable tumor entity within only one decade. The understanding of GIST biology has made this tumor a paradigm for molecularly targeted therapy in solid tumors and provides informative insights into the ...
Bernadette, Liegl-Atzwanger +2 more
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Gastrointestinal Endoscopy, 2003
GI stromal tumors (GIST) previously were thought to represent smooth muscle tumors of the GI tract and were formerly classified as leiomyomas and leiomyosarcomas. Within the past decade, there have been several major scientific advances in the understanding of these tumors, their possible origin, and pathogenesis, and this in turn has greatly impacted ...
Raquel E, Davila, Douglas O, Faigel
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GI stromal tumors (GIST) previously were thought to represent smooth muscle tumors of the GI tract and were formerly classified as leiomyomas and leiomyosarcomas. Within the past decade, there have been several major scientific advances in the understanding of these tumors, their possible origin, and pathogenesis, and this in turn has greatly impacted ...
Raquel E, Davila, Douglas O, Faigel
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Gastrointestinal Stromal Tumors
Current Oncology ReportsThis review aims to outline the current understanding of the molecular drivers and treatment paradigms of gastrointestinal stromal tumors, with a focus on recent developments in treatment in the advanced disease setting.There have been recent advancements in our understanding of the molecular biology of gastrointestinal stromal tumors, including the ...
Gal, Strauss, Suzanne, George
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GASTROINTESTINAL STROMAL TUMOR
2010Gastrointestinal stromal tumor, i.e., GIST is by far the most common mesenchymal tumor of the gastrointestinal tract. GIST has received special clinical attention, because it is one of the first solid tumors treated with tyrosine kinase inhibitors as targeted oncological therapy.
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Malignant gonadal stromal tumor
Urology, 1994A case of malignant gonadal stromal tumor is reported, and the 24 cases reported in the English and Japanese literature are reviewed. A thirty-four-year-old male visited our hospital with a painless tumor in the left scrotum. Left high orchiectomy was performed under a diagnosis of testicular tumor, and histologic examination of the resected specimen ...
K, Gohji +3 more
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Gastrointestinal stromal tumor (GIST)
Current Treatment Options in Gastroenterology, 2006Gastrointestinal stromal tumors (GISTs), the most common nonepithelial neoplasms of the gastrointestinal (GI) tract, occur most commonly in the stomach. These neoplasms were previously classified as smooth muscle tumors, but it has become apparent that they represent distinct clinicopathologic entities.
Mitchell L, Schubert, Robert, Moghimi
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Gastrointestinal stromal tumors
Current Treatment Options in Oncology, 2000The nonepithelial, nonlymphoid tumors of the gastrointestinal tract are heterogeneous in terms of clinical presentation, behavior, pathology, and genetic features. Concepts regarding these tumors have changed rapidly over the past decade as nomenclature has evolved. Many of these tumors have no muscle differentiation, and designations such as leiomyoma
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Gastrointestinal stromal tumors (GISTs)
Current Opinion in Gastroenterology, 2004Gastrointestinal stromal tumors (GISTs) have recently been the subject of considerable clinical and experimental interest. This focus is based on the recognition that GISTs characteristically have uncontrolled activation of the KIT protein, a transmembrane tyrosine kinase receptor involved in cell survival, development, and proliferation.
Mandeep S, Saund +2 more
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