Results 31 to 40 of about 1,904 (239)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Biscogniauxia repanda, B. marginata and Camarops polysperma (Pyrenomycetes) in Poland and Lithuania

Acta Mycologica, 2014
In the present paper, Biscogmauxia repanda, B. marginata and Camarops polysperma are resported from Poland and Lithuania. Pseudotrichia mutabilis been noted on old stromata of B. marginata from Lithuania.
Andrzej Chlebicki, Anna Bujakiewicz
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Epichloë clarkii - a new graminicolous species for Poland

Acta Mycologica, 2014
Epichloë clarkii White, described in 1993 from England has been noted from Wielkopolski National Park in Poland. The eggs and feed marks of hyperparasitic fly, Botanophila sp. have been found on teleomorph stromata of E. clarkii.
Andrzej Chlebicki, Piotr Szkularz
doaj   +1 more source

Initial Study on Physiochemical Property and Antibacterial Activity against Skin-Infecting Bacteria of Silver Nanoparticles Biologically Produced Using Crude Melanin from Xylaria sp.

Cosmetics, 2023
Silver nanoparticles (AgNPs) produced by biological methods are safer for biomedical applications. Melanins were initially reported to facilitate AgNPs synthesis.
Linh Doan, Nhu K. H. Vo, Hanh T. M. Tran
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Problem definicji wiary w "Dywanach" Klemensa Aleksandryjskiego

Vox Patrum, 1986
In articulo "De problemate definitionis fldei in Stromateis Clementis de Alexandria" haec continentur, quae methodo structurali in toto complexu verbi pistis investigata sunt.
Henryk Ostrowski
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

In recognition of Ricardo Sánchez Ortiz de Urbina: personal testimonies

Eikasía
Several testimonials from students of Ricardo Sánchez Ortiz de Urbina are included as a tribute to him and to highlight his philosophical work, as well as his contribution to the public Philosophy program in Valladolid.
Jesús M. Hernández Velasco, Nuria Galicia Pérez, Luis Riera Climent   +2 more
doaj   +1 more source