Results 31 to 40 of about 1,975 (248)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Epichloë clarkii - a new graminicolous species for Poland

open access: yesActa Mycologica, 2014
Epichloë clarkii White, described in 1993 from England has been noted from Wielkopolski National Park in Poland. The eggs and feed marks of hyperparasitic fly, Botanophila sp. have been found on teleomorph stromata of E. clarkii.
Andrzej Chlebicki, Piotr Szkularz
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Problem definicji wiary w "Dywanach" Klemensa Aleksandryjskiego

open access: yesVox Patrum, 1986
In articulo "De problemate definitionis fldei in Stromateis Clementis de Alexandria" haec continentur, quae methodo structurali in toto complexu verbi pistis investigata sunt.
Henryk Ostrowski
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

In recognition of Ricardo Sánchez Ortiz de Urbina: personal testimonies

open access: yesEikasía
Several testimonials from students of Ricardo Sánchez Ortiz de Urbina are included as a tribute to him and to highlight his philosophical work, as well as his contribution to the public Philosophy program in Valladolid.
Jesús M. Hernández Velasco   +2 more
doaj   +1 more source

Initial Study on Physiochemical Property and Antibacterial Activity against Skin-Infecting Bacteria of Silver Nanoparticles Biologically Produced Using Crude Melanin from Xylaria sp.

open access: yesCosmetics, 2023
Silver nanoparticles (AgNPs) produced by biological methods are safer for biomedical applications. Melanins were initially reported to facilitate AgNPs synthesis.
Linh Doan, Nhu K. H. Vo, Hanh T. M. Tran
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Antimicrobial and Antioxidant Activities of Some Xylariaceous Fungi

open access: yesBiotropika: Journal of Tropical Biology
The Xylariaceae family comprises cosmopolitan ascomycetous fungi that predominantly live as saprobes, contributing ecologically and forming interactions with various organisms.
Desimaria Panjaitan   +4 more
doaj   +1 more source

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