Results 111 to 120 of about 1,344,024 (249)

Transonic Turbulence and Density Fluctuations in the Near-Sun Solar Wind

The Astrophysical Journal Letters
We use in situ measurements from the first 19 encounters of Parker Solar Probe and the most recent five encounters of Solar Orbiter to study the evolution of the turbulent sonic Mach number M _t (the ratio of the amplitude of velocity fluctuations to the
L.-L. Zhao, A. Silwal, X. Zhu, H. Li, G. P. Zank   +4 more
doaj   +1 more source

The intestinal Stenotrophomonas maltophilia ZG-GX enhances the resistance of Spodoptera frugiperda to beta-cypermethrin and decreases the amino acid levels

Microbiology Spectrum
Spodoptera frugiperda is an invasive agricultural pest with a high tolerance for chemical insecticides. An increasing number of studies have reported that intestinal microbes of insects can affect host resistance to insecticides. Therefore, in this study,
Yong Duan, Daozhen Luo, Banghong Jian, Liang Wu, Hao Yang, Chunyu Hu, Yang Zhao   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Improvement of Seed Germination, Seedling Vigor and Yield of Achillea santolina and A. millefolium by Physical Priming Techniques [PDF]

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī, 2018
To study the effect of physical primings on growth and yield of Achillea santolina and A. millefolium two experiments were conducted in Islamic Azad University of Tabriz, Iran, with three replications during 2014.
Bahram Mirshekari
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Optimal Network Analysis through Vertex Order Coloring of Intuitionistic Fuzzy Graph Operations

Journal of Mathematics
Intuitionistic fuzzy graphs IFGs are a powerful tool for modeling uncertainty and complex relationships. They offer versatile frameworks for addressing real-world challenges. In this research, we have introduced intuitionistic fuzzy vertex order coloring
A. Meenakshi, S. Dhanushiya, Hong Qin, Muniyandy Elangovan   +3 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Major Depression in Children with β-Thalassemia Major is Strongly Associated with the Number of Blood Transfusions, Iron Overload and Increased Levels of Interleukin-1β

, 2019
Hussein Kadhem Al‐Hakeim, Asawer Hassan Najm, Arafat Hussein Al-Aldujaili, Michaël Maes   +3 more
openalex   +2 more sources

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source