Results 101 to 110 of about 13,075,262 (257)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

pynbody/pynbody: v2.0.0-beta.5

<h2>What's Changed</h2> <ul> <li>Return children from SubfindHDF get_properties_all_halos by @apontzen in https://github.com/pynbody/pynbody/pull/783</li> </ul> <p><strong>Full Changelog</strong> ...
mihaimt, Alex Ji, nroth0815, Ben Keller, mkrets, Tommaso Zana, Jon Davies, Jo Bovy, Corentin Cadiou, Elaad Applebaum, Michele Mastropietro, Jonathan Coles, Richard Shaw, Thomas Quinn, Andrew Pontzen, EthTay, Martin P. Rey, Eva Franck, Rok Roškar, Rory Woods, Greg Stinson, A R Duffy, Jakob Herpich, Lukas Winkler, Rick Sarmento, Gabriel Altay, Michael Tremmel, Pawel Biernacki   +27 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Understanding the formation of a low-pressure pedestal in the presence of a strong internal transport barrier in DIII-D high βp plasmas

Nuclear Fusion
As a promising scenario for fusion reactors, the high poloidal-beta ( ${\beta _{\text{P}}}$ ) scenario is characterized by a strong large radius internal transport barrier (ITB), which significantly enhances the overall confinement quality and the ...
X.R. Zhang, X. Jian, Y.R. Zhu, Y.P. Zou, Z.Y. Li, Y.J. Zhou, L.Z. Liu, S. Zheng, Z.X. Wang, W. Chen, S.Y. Ding, A.M. Garofalo, V.S. Chan, G.Q. Li   +13 more
doaj   +1 more source

barbarahelena/vsearchpipeline: v.0.7.1-beta

<p><strong>Full Changelog</strong>: https://github.com/barbarahelena/vsearchpipeline/compare/v.0.7-beta...v.0.7.1-beta</p> <p>Update fastqc and multiqc nf-core modules.
Barbara Verhaar
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Beta-defensin genomic copy number is not a modifier locus for cystic fibrosis.

, 2005
Human beta-defensin 2 (DEFB4, also known as DEFB2 or hBD-2) is a salt-sensitive antimicrobial protein that is expressed in lung epithelia. Previous work has shown that it is encoded in a cluster of beta-defensin genes at 8p23.1, which varies in copy ...
E. W. Alton (7620476), J. A. Armour (7607630), J. Burgess (7620473), J. Davies (766952), U. Griesenbach (7620470), Edward J. Hollox (7583051)   +5 more
core   +3 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

lgrcia/spotter: 0.0.6-beta

<h2>What's Changed</h2> <ul> <li>fix: add projected area by @lgrcia in https://github.com/lgrcia/spotter/pull/18</li> <li>tests+fix: starry comparison (flux) by @lgrcia in https://github.com/lgrcia/spotter/pull/19< ...
Benjamin V. Rackham, Lionel J. Garcia
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source