Results 81 to 90 of about 843,378 (261)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
pynbody/pynbody: v2.0.0-beta.5 [PDF]
<h2>What's Changed</h2> <ul> <li>Return children from SubfindHDF get_properties_all_halos by @apontzen in https://github.com/pynbody/pynbody/pull/783</li> </ul> <p><strong>Full Changelog</strong> ...
mihaimt +27 more
core +1 more source
Exogenous Ghrelin Increases Plasma Insulin Level in Diabetic Rats
Biomolecules, 2020 Ghrelin, a 28-amino acid peptide, is a strong growth hormone secretagogue and a regulator of food intake. In addition, ghrelin is thought to play a role in insulin secretion and in glucose homeostasis.
Haba Elabadlah +4 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
barbarahelena/vsearchpipeline: v.0.7.1-beta [PDF]
<p><strong>Full Changelog</strong>: https://github.com/barbarahelena/vsearchpipeline/compare/v.0.7-beta...v.0.7.1-beta</p> <p>Update fastqc and multiqc nf-core modules.
Barbara Verhaar
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
lgrcia/spotter: 0.0.6-beta [PDF]
<h2>What's Changed</h2> <ul> <li>fix: add projected area by @lgrcia in https://github.com/lgrcia/spotter/pull/18</li> <li>tests+fix: starry comparison (flux) by @lgrcia in https://github.com/lgrcia/spotter/pull/19< ...
Benjamin V. Rackham, Lionel J. Garcia
core +1 more source
Causal evidence that intrinsic beta frequency is relevant for enhanced signal propagation in the motor system as shown through rhythmic TMS [PDF]
, 2016 Correlative evidence provides support for the idea that brain oscillations underpin neural computations. Recent work using rhythmic stimulation techniques in humans provide causal evidence but the interactions of these external signals with intrinsic ...
Brooks, Joseph L. +16 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source