Results 141 to 150 of about 1,202,304 (236)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Temporal Structure of Item Presentation Modulates Brain Oscillations in Verbal Working Memory. [PDF]

Eur J Neurosci
Kosachenko AI, Syttykov DI, Tarasov DA, Kotyusov AI, Kasanov D, Malykh S, Kotchoubey B, Pavlov YG.   +7 more
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody

Journal of Cellular Biochemistry, 2012
Xianglin Wu, M. Subramaniam, V. Negron, M. Cicek, C. Reynolds, W. Lingle, M. Goetz, J. Ingle, T. Spelsberg, J. Hawse   +9 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid-beta drugs in Alzheimer's disease: a Bayesian meta-analysis. [PDF]

J Comp Eff Res
Ren S, Singh J, Gsteiger S, Cogley C, Reed B, Abrams KR, Dawoud D, Owen RK, Tappenden P, Quinn TJ, Bujkiewicz S.   +10 more
europepmc   +1 more source

Type 1 and type 2 cytokine dysregulation in human infectious, neoplastic, and inflammatory diseases

Clinical Microbiology Reviews, 1996
Daniel Lucey, M. Clerici, G. Shearer
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A Novel Method for Generating Spatially Resolved Synthetic Populations for Health Impact Assessments in Vulnerable Populations. [PDF]

Geohealth
Black-Ingersoll F, Milando CW, Popp ZT, Echevarría-Ramos M, Fabian MP, Nori-Sarma A, Levy JI.   +6 more
europepmc   +1 more source

Evidence-Based Supplements for the Enhancement of Athletic Performance.

International Journal of Sport Nutrition & Exercise Metabolism, 2018
P. Peeling, M. Binnie, P. Goods, M. Sim, L. Burke   +4 more
semanticscholar   +1 more source