Results 161 to 170 of about 843,378 (261)

Evaluating therapeutic efficacy of iopanoic acid in a DMM-induced osteoarthritis mouse model and osteochondral lesioned human explants. [PDF]

Osteoarthr Cartil Open
Sayedipour SS, Mazzini G, Tuerlings M, Nikkels J, Koedam M, Cruz LJ, Mahdad R, de Weerd L, van der Eerden B, Ramos YF, Meulenbelt I.   +10 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Seasonality and Grazing Exclusions Shape Bird Community Dynamics in West African Drylands. [PDF]

Ecol Evol
Kuttnig A, Zongo AN, Quintas I, Fritsche L, Spaar R, Diakité B, Kaguembèga-Müller F, Jacot A, Rumpf SB, Marcacci G.   +9 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

On the beta-number of forests with isomorphic components [PDF]

The beta-number, ß (G), of a graph G is defined to be either the smallest positive integer n for which there exists an injective function f : V (G) ¿ {0, 1, . . .
Oshima, Akito, López Masip, Susana Clara, Ichishima, R., Muntaner Batle, Francesc Antoni   +3 more
core  

Genomics-informed approach identifies which cell types regulate the metabolome. [PDF]

Bioinformatics
Krupkin H, Padhi EM, Nachun D, Kain J, Long JZ, Montgomery SB.   +5 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Predicting Theta/Alpha Neurofeedback Success through Psychological and Personality Profiles: A Hybrid Approach Using Multilayer Perceptron and Elastic Net Models. [PDF]

J Med Signals Sens
Hasheminia S, Sho'ouri N, Mahmoudi MT.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Phloridzin mitigates bleomycin-elicited lung fibrosis in Wistar rats: The interplay between antioxidant defenses, inflammatory processes, transforming growth factor beta 1, and autophagy. [PDF]

Toxicol Rep
Alenezi NMF, Elkhoely A, Kabel AM, Ahmed AAE.   +3 more
europepmc   +1 more source