Results 141 to 150 of about 13,075,262 (257)

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Evidence for Reductions in Fungal Richness and Beta Diversity Dispersion Associated With Impervious Surfaces in California. [PDF]

Ecol Evol
Simons AL, Timlin-Broussard C, Willis A, Lee J.   +3 more
europepmc   +1 more source

emmo-repo/domain-electrochemistry: 0.12.1-beta

<h2>What's Changed</h2> <p>This is a patch to update the versioning to remove the "v" prefix from the tags, in accordance with EMMO recommendations.</p> <p><strong>Full Changelog</strong>: https ...
Simon Clark, Jesper Friis, Casper Welzel Andersen, Eibar Flores, Xavier Raynaud, Francesca L. Bleken   +5 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

LabSid-USP/RUBEMHydrological: RUBEM Hydrological v1.12.3-beta.3

<h2>What's Changed</h2> <ul> <li>Fix <code>plotTimeSeriesData function</code> to use numpy arrays for plotting by @soaressgabriel in https://github.com/LabSid-USP/RUBEMHydrological/pull/136</li> </ul> <p&
camilabillerbeck, wdvichete84, Daniel Manabe Pasetti, LINA OSORIO, Gabriel Soares   +4 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Patterns and Environmental Drivers of Amphibian Alpha and Beta Diversity in the Huangshan Mountains, Southern Anhui, China. [PDF]

Ecol Evol
Wang S, Wang Z, Sun Y, He Z, Sun Q, Wei J, Li Y, Liu M, Shi J, Zhang C, Wu S, Bai Y, Zhang Z, Zhao N, Wang S.   +14 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Nitrogen fertilization outweighs plant species loss in shaping bacterial belowground diversity in an alpine meadow on the central Tibetan Plateau. [PDF]

FEMS Microbiol Ecol
Wu D, Quzong C, Jia Z, Schwalb A, Guggenberger G, Wang S, Dorji T, Pester M.   +7 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source