Results 171 to 180 of about 13,075,262 (257)

Maternal parenting and the development of adolescent self-esteem: A longitudinal twin study. [PDF]

J Res Adolesc
Lim J, Guo J, Klatzka CH, Teuber Z.
europepmc   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Metagenomic and metabolomic analysis of the early gut microbiota development in <i>Nipponia nippon</i>. [PDF]

Front Microbiol
Bai H, Qiu G, Shi J, Xue Y, Dai W, Liu Q, Zhou X, He K.   +7 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Contrasting reproductive strategies and their functional consequences in two populations of Opuntia robusta (Cactaceae). [PDF]

BMC Plant Biol
Mendoza-Reyes CHS, Miranda-Pérez A, Núñez-Farfán J, Janczur MK.   +3 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Targeting KPC-Producing <i>Klebsiella pneumoniae</i> Biofilms: Genomic Profiles, Clinical Outcomes and Novel Combinations. [PDF]

Microorganisms
Papalini C, Bicchieraro G, Tordelli Ruda L, Wong AYW, Battistelli C, Genga G, Tommasi A, Gidari A, Francisci D, Socio GV, Spaccapelo R, Pietrella D, Mencacci A, Monari C, Sabbatini S.   +14 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Drug Utilization Patterns and Potential Drug-Drug Interaction Burden in Respiratory Prescriptions: A Real-World Community Pharmacy Study. [PDF]

Pharmaceuticals (Basel)
Drăgoi MM, Chis AR, Ardelean SM, Udrescu M, Suciu L, Udrescu L.   +5 more
europepmc   +1 more source