Results 51 to 60 of about 1,344,024 (249)

NEBIVOLOL IN TREATMENT OF STABLE EXERTIONAL ANGINA PECTORIS

Рациональная фармакотерапия в кардиологии, 2015
Aim. To evaluate antianginal and antiischemic efficiency of nebivolol in patients with stable angina pectoris.Material and methods. 100 patients with ischemic heart disease showing stable exertional angina pectoris and having no contraindications to beta-
Y. V. Gavrilov, V. A. Sulimov, V. I. Makolkin   +2 more
doaj   +1 more source

On the Littlewood conjecture in simultaneous Diophantine approximation [PDF]

, 2005
For any given real number $\alpha$ with bounded partial quotients, we construct explicitly continuum many real numbers $\beta$ with bounded partial quotients for which the pair $(\alpha, \beta)$ satisfies a strong form of the Littlewood conjecture.
Adamczewski, Boris, Bugeaud, Yann
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Metabolic Profile and Inflammatory Responses in Dairy Cows with Left Displaced Abomasum Kept under Small-Scaled Farm Conditions

Animals, 2015
Left displaced abomasum (LDA) is a severe metabolic disease of cattle with a strong negative impact on production efficiency of dairy farms. Metabolic and inflammatory alterations associated with this disease have been reported in earlier studies ...
Fenja Klevenhusen, Elke Humer, Barbara Metzler-Zebeli, Leopold Podstatzky-Lichtenstein, Thomas Wittek, Qendrim Zebeli   +5 more
doaj   +1 more source

Bayesian analysis to identify new star candidates in nearby young stellar kinematic groups

, 2012
We present a new method based on a Bayesian analysis to identify new members of nearby young kinematic groups. The analysis minimally takes into account the position, proper motion, magnitude and color of a star, but other observables can be readily ...
Adelman-McCarthy, Adric Riedel, Bailey, Baraffe, Barrado y Navascués, Barrado y Navascués, Bobylev, Bowler, Chen, Cutri, David Lafrenière, de La Reza, de la Reza, de la Reza, Donati, Donati, Doyon, Eggen, Epchtein, Faherty, Frédérique Baron, Gizis, Gizis, Gliese, Helou, Herbig, Høg, Janson, Jayawardhana, Jonathan Gagné, Kharchenko, Landolt, Lepine, Lison Malo, Looper, Luhman, Lépine, López-Santiago, Makarov, Mamajek, Mamajek, Mamajek, Mazeh, Mentuch, Mohanty, Moór, Nakajima, Nakajima, Ortega, Ortega, Perryman, Reid, Reid, Reid, René Doyon, Riaz, Rice, Riedel, Rodriguez, Roeser, Roeser, Rucinski, Salim, Schlieder, Schlieder, Schlieder, Shkolnik, Shkolnik, Shkolnik, Siebert, Skrutskie, Song, Song, Song, Steinmetz, Stelzer, Tetzlaff, Torres, Torres, Torres, Voges, Wahhaj, Webb, White, Zacharias, Zacharias, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zuckerman, Zwitter, Étienne Artigau   +93 more
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves [PDF]

, 2006
During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo.
D'Antonio, M, Droggiti, A, Feltri, ML, Jessen, KR, Mirsky, R, Roes, J, Wrabetz, L   +6 more
core  

Physical properties and small-scale structure of the Lyman-alpha forest: Inversion of the HE 1122-1628 UVES spectrum [PDF]

, 2001
We study the physical properties of the Lyman-alpha forest by applying the inversion method described by Pichon et al. (2001) to the high resolution and high S/N ratio spectrum of the z_em=2.40 quasar HE 1122-1628 obtained during Science Verification of ...
Anninos, Arnaud, C. Pichon, Carswell, Cen, Choudhury, Cowie, Crotts, D'Odorico, Davidsen, Dinshaw, Dinshaw, E. Rollinde, Ellison, Ellison, Fang, Giallongo, Hellsten, Hernquist, Hu, Hui, Impey, Kim, Lucy, Mc Donald, Miralda-Escudé, Mücket, Nusser, Nusser, P. Petitjean, Petitjean, Petitjean, Pettini, Rauch, Ricotti, Riediger, Savaglio, Schaye, Smette, Songaila, Weymann, Young   +41 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source