Results 71 to 80 of about 543,055 (305)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
On a Simplified Method of Defining Characteristic Function in Stochastic Games
Mathematics, 2020 In the paper, we propose a new method of constructing cooperative stochastic game in the form of characteristic function when initially non-cooperative stochastic game is given. The set of states and the set of actions for any player is finite.
Elena Parilina, Leon Petrosyan
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Uniform Consistency for Nonparametric Estimators in Null Recurrent Time Series [PDF]
This paper establishes several results for uniform convergence of nonparametric kernel density and regression estimates for the case where the time series regressors concerned are nonstationary null–recurrent Markov chains.
Dag Tjostheim, Jiti Gao, Degui Li
core +2 more sources
Strong Consistency of Certain Sequential Estimators
The Annals of Mathematical Statistics, 1969 Motivated by Loynes' (1969) treatment of (weak) consistency of sequential estimators, we establish here some allied results on strong consistency. The strengthened conclusion is achieved by imposing further restrictions, so that our results are not as broadly applicable as Loynes'.
openaire +3 more sources
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Pointwise universal consistency of nonparametric density estimators. [PDF]
This paper presents sufficient conditions for pointwise universal consistency of nonparametric delta estimators and shows the application of these conditions for some classes of nonparametric estimators.Delta estimators; Pointwise approximation ...
Vidal-Sanz, Jose M.
core
Maximum Likelihood Estimation in the Fractional Vasicek Model
Lithuanian Journal of Statistics, 2017 We consider the fractional Vasicek model of the form dXt = (α-βXt)dt +γdBHt , driven by fractional Brownian motion BH with Hurst parameter H ∈ (1/2,1).
Stanislav Lohvinenko +1 more
doaj +1 more source