Results 81 to 90 of about 543,055 (305)
Journal of Inequalities and Applications, 2020 With the increasing availability of spatially extensive geo-referenced data, much attention has been paid to the use of local statistics to identify local patterns of spatial association, in which the null distributions of local statistics play an ...
Chang-Lin Mei, Shou-Fang Xu, Feng Chen
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
POINTWISE UNIVERSAL CONSISTENCY OF NONPARAMETRIC LINEAR ESTIMATORS [PDF]
This paper presents sufficient conditions for pointwise universal consistency of nonparametric delta estimators. We show the applicability of these conditions for some classes of nonparametric estimators.
Jose M. Vidal-Sanz
core
Modern Stochastics: Theory and ApplicationsThe problem of estimating the drift parameter is considered for an Ornstein–Uhlenbeck-type process driven by a tempered fractional Brownian motion (tfBm) or tempered fractional Brownian motion of the second kind (tfBmII).
Olha Prykhodko, Kostiantyn Ralchenko
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Strong consistency rates for the estimators in a heteroscedastic EV model with missing responses
Journal of Inequalities and Applications, 2020 This article is concerned with the semi-parametric error-in-variables (EV) model with missing responses: y i = ξ i β + g ( t i ) + ϵ i $y_{i}= \xi _{i}\beta +g(t_{i})+\epsilon _{i}$ , x i = ξ i + μ i $x_{i}= \xi _{i}+\mu _{i}$ , where ϵ i = σ i e i ...
Jing-Jing Zhang, Yun-Peng Xiao
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Local Linear Fitting Under Near Epoch Dependence: Uniform consistency with Convergence Rates [PDF]
Local linear fitting is a popular nonparametric method in statistical and econometric modelling. Lu and Linton (2007) established the pointwise asymptotic distribution for the local linear estimator of a nonparametric regression function under the ...
Zudi Lu, Degui Li, Oliver Linton
core
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source