Results 41 to 50 of about 194,045 (291)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Strong Convergence of Modified Halpern Iterations in CAT(0) Spaces

Fixed Point Theory and Applications, 2011
Strong convergence theorems are established for the modified Halpern iterations of nonexpansive mappings in CAT(0) spaces. Our results extend and improve the recent ones announced by Kim and Xu (2005), Hu (2008), Song and Chen (2008), Saejung (2010 ...
A. Cuntavepanit, B. Panyanak
doaj   +2 more sources

Strong Convergence of an Implicit Algorithm in CAT(0) Spaces

Fixed Point Theory and Applications, 2011
We establish strong convergence of an implicit algorithm to a common fixed point of a finite family of generalized asymptotically quasi-nonexpansive maps in CAT spaces. Our work improves and extends several recent results from the current literature.
Domlo AbdulAziz, Khan AbdulRahim, Fukhar-ud-din Hafiz   +2 more
doaj   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Strong Convergence of Generalized Projection Algorithms for Nonlinear Operators

Abstract and Applied Analysis, 2009
We establish strong convergence theorems for finding a common element of the zero point set of a maximal monotone operator and the fixed point set of two relatively nonexpansive mappings in a Banach space by using a new hybrid method.
Chakkrid Klin-eam, Suthep Suantai, Wataru Takahashi   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Strong Whitney convergence on bornologies

Filomat, 2022
The strong Whitney convergence on bornology introduced by Caserta in [9] is a generalization of the strong uniform convergence on bornology introduced by Beer-Levi in [5]. This paper aims to study some important topological properties of the space of all real valued continuous functions on a metric space endowed with the topologies of ...
Tarun Chauhan, Varun Jindal
openaire   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Strong almost convergence and almost λ-statistical convergence

Hokkaido Mathematical Journal, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source