Results 51 to 60 of about 194,045 (291)
Nonlinear AnalysisRecently in [V. Berinde and M. Păcurar, Approximating fixed points of enriched Chatterjea contractions by Krasnoselskij iterative algorithm in Banach spaces, J.
Thitima Kesahorm, Wutiphol Sintunavarat
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
A Nesterov type algorithm with double Tikhonov regularization: fast convergence of the function values and strong convergence to the minimal norm solution [PDF]
, 2023 Mikhail Karapetyants +1 more
openalex +1 more source
The Strong Convergence of Schrodinger Propagators [PDF]
Transactions of the American Mathematical Society, 1981 Time dependent versions of the Trotter-Kato theorem are discussed using nonstandard analysis. Both standard and nonstandard results are obtained. In particular, it is shown that if a sequence of generators converges in the strong resolvent topology at each time to a limiting generator and if the sequence of generators and limiting generator uniformly ...
openaire +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
An extrapolated fixed-point optimization method for strongly convex smooth optimizations
AIMS MathematicsIn this work, we focused on minimizing a strongly convex smooth function over the common fixed-point constraints. We proposed an extrapolated fixed-point optimization method, which is a modified version of the extrapolated sequential constraint method ...
Duangdaw Rakjarungkiat, Nimit Nimana
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Strong Convergence of Viscosity Iteration Methods for Nonexpansive Mappings
Abstract and Applied Analysis, 2009 We propose a new viscosity iterative scheme for finding fixed points of nonexpansive mappings in a reflexive Banach space having a uniformly Gâteaux differentiable norm and satisfying that every weakly compact convex subset of the space has the fixed ...
Jong Soo Jung
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