Results 71 to 80 of about 241,544 (303)

Strong boundedness, strong convergence and generalized variation [PDF]

open access: yesActa Mathematica Hungarica, 2017
14 ...
Avdispahić, M., Šabanac, Z.
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Strong Convergence of Viscosity Iteration Methods for Nonexpansive Mappings

open access: yesAbstract and Applied Analysis, 2009
We propose a new viscosity iterative scheme for finding fixed points of nonexpansive mappings in a reflexive Banach space having a uniformly Gâteaux differentiable norm and satisfying that every weakly compact convex subset of the space has the fixed ...
Jong Soo Jung
doaj   +1 more source

Local Linear Fitting Under Near Epoch Dependence: Uniform consistency with Convergence Rates [PDF]

open access: yes
Local linear fitting is a popular nonparametric method in statistical and econometric modelling. Lu and Linton (2007) established the pointwise asymptotic distribution for the local linear estimator of a nonparametric regression function under the ...
Zudi Lu, Degui Li, Oliver Linton
core  

On the convergence of adaptive nonconforming finite element methods for a class of convex variational problems [PDF]

open access: yes, 2011
We formulate and analyze an adaptive nonconforming finite element method for the solution of convex variational problems. The class of minimization problems we admit includes highly singular problems for which no Euler–Lagrange equation (or inequality ...
Christoph Ortner   +3 more
core   +1 more source

Strong Convergence of Distributions of Estimators

open access: yesThe Annals of Statistics, 1987
Let the parameter space \(\theta\) be an open subset of R k and \(\{T_ n\}^ a \)sequence of estimators of \(\vartheta\in \theta\). Assuming that the locally asymptotically normal condition is satisfied at \(\vartheta_ 0\in \theta\), the author obtained a sufficient condition which assures that for all \(\alpha >0\lim_{n\to \infty}\sup_{| h| \leq \alpha}
openaire   +3 more sources

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha   +4 more
wiley   +1 more source

Relative entropy in diffusive relaxation [PDF]

open access: yes, 2012
We establish convergence in the diffusive limit from entropy weak solutions of the equations of compressible gas dynamics with friction to the porous media equation away from vacuum.
Tzavaras, Athanasios E.   +1 more
core   +1 more source

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