Results 91 to 100 of about 3,838,631 (296)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

On Some Further Generalizations of Strong Convergence in Probabilistic Metric Spaces Using Ideals

open access: yesAbstract and Applied Analysis, 2013
Following the line of (Das et al., 2011, Savas and Das, 2011), we make a new approach in this paper to extend the notion of strong convergence and more general strong statistical convergence (Şençimen and Pehlivan, 2008) using ideals and introduce the ...
Pratulananda Das   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

open access: yesMolecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

On the Strong Approximation of Pure Jump Processes [PDF]

open access: yes
This paper constructs strong discrete time approximations for pure jump processes that can be described by stochastic differential equations. Strong approximations based on jump-adapted time discretizations, which produce no discretization bias, are ...
Nicola Bruti-Liberati, Eckhard Platen
core  

Strong convergence of estimators as ε n -minimisers of optimisation problemsof optimisation problems [PDF]

open access: yes, 2010
Strong convergence, M-estimators, epi-convergence, stochastic optimisation,
Silvia Vogel   +3 more
core   +1 more source

Strong Convergence Theorems for a Pair of Strictly Pseudononspreading Mappings

open access: yesJournal of Mathematics, 2013
Let H be a real Hilbert space. Let T1,T2:H→H be k1-, k2-strictly pseudononspreading mappings; let αn and βn be two real sequences in (0,1). For given x0∈H, the sequence xn is generated iteratively by xn+1=βnxn+1-βnTw1αnγfxn+I-μαnBTw2xn, ∀n∈N, where Twi=1−
Bin-Chao Deng, Tong Chen
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

A rate of convergence in clustering analysis. [PDF]

open access: yes
We present a result about stochastic boundedness of stable empirical processes on Vapnik-Cervonenkis classes of functions and we apply it to obtain a rate of convergence for the approximation between the sample and the populational variation in the k ...
Romo, Juan
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Strong Convergence Theorems of the CQ Method for Nonexpansive Semigroups

open access: yesFixed Point Theory and Applications, 2007
Motivated by T. Suzuki, we show strong convergence theorems of the CQ method for nonexpansive semigroups in Hilbert spaces by hybrid method in the mathematical programming.
Huimin He, Rudong Chen
doaj   +1 more source

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