Results 51 to 60 of about 69,901 (264)
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Geomatics, Natural Hazards & Risk, 2016 We focused on validation of applicability of semi-empirical technique (spectral models and stochastic simulation) for the estimation of ground-motion characteristics in the northeastern region (NER) of India.
Dipok K. Bora +2 more
doaj +1 more source
Communications Earth & Environment, 2023 Damages due to large earthquakes are influenced by broadband source effects that remain enigmatic. Here we develop a broadband (0–10 Hz) source model of the disastrous 2023 Mw7.8 Kahramanmaraş, Türkiye, earthquake by modeling recordings of 100 stations ...
František Čejka +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Ground motion prediction equation for NW Himalaya and its surrounding region
Quaternary Science AdvancesAn attenuation relationship, also known as a Ground Motion Prediction Equation (GMPE), has been developed for the Northwest Himalaya and its surrounding region.
Vandana +3 more
doaj +1 more source
The Preliminary Study of the 4 March 2010 Mw 6.3 Jiasian, Taiwan Earthquake Sequence
Terrestrial, Atmospheric and Oceanic Sciences, 2011 On 4 March 2010, an inland Mw 6.3 earthquake occurred near the town of Jiasian in Kaohsiung County, Taiwan causing large ground shaking and extensive damage.
Hsin-Hua Huang +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Prediction Equation for Horizontal Ground Motion Peak Values in the Loess Plateau Region
Applied SciencesThis study collects all strong motion records from 134 seismic events in the Loess Plateau region of China between 2020 and 2023. The corresponding ground motion attenuation dataset is constructed through data processing and screening, including 1149 ...
Wei Wan, Jingshan Bo, Da Peng
doaj +1 more source