Results 121 to 130 of about 2,913 (200)

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

From "More Is Different" to Algorithmic Emergence: Regularity, Compression, and the Limits of Discovery. [PDF]

Entropy (Basel)
Ruffini G, Castaldo F.
europepmc   +1 more source

Climate Protest and Firm ESG Performance: Elucidating Global North–South Inequalities

Corporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT In response to calls to keep global warming below 1.5°C, firms have employed responsible business practices in their operations. Neglecting their normative and ontological ethical obligations to their stakeholders has often attracted climate protests, posing a potential risk to business operations and their reputation by threatening their ...
Peter Adjei‐Bamfo, Alfred Wong, Roman Meinhold, Alain Neher, Justice N. Bawole   +4 more
wiley   +1 more source

Testing for Genetic Interactions in Complex Disease With Distance Correlation. [PDF]

Biom J
Castro-Prado F, Costas J, Edelmann D, González-Manteiga W, Penas DR.   +4 more
europepmc   +1 more source

Improved Conservative Scheme for Lenard‐Bernstein Collisions in Gyrokinetic Turbulence Simulations

Contributions to Plasma Physics, EarlyView.
ABSTRACT Turbulence in the edge and scrape‐off layer regions plays a critical role for the performance of future magnetic confinement fusion power plants. Gyrokinetic simulations allow studying this regime with high fidelity. A key aspect in these regions is the high concentration of impurities, which can radiate energy, leading to significant losses ...
Andrew Ivan Sulimro, Philipp Ulbl, Jordy Trilaksono, Frank Jenko   +3 more
wiley   +1 more source

Inverse-Probability-Weighted Kernel Estimation of Regression Derivatives Under Missing-at-Random Responses for Stationary Ergodic Processes. [PDF]

Entropy (Basel)
Bouzebda S, Didi S.
europepmc   +1 more source

Upper bound limit analysis of coral reef limestone cavern roof stability incorporating a tension‐shear failure mechanism with tensile‐strength cut‐off

Deep Underground Science and Engineering, EarlyView.
For the roof of coral reef limestone caverns, a novel tension‐shear composite failure mechanism was developed. The most critical tensile crack model was identified using a hybrid optimization algorithm, and the stability of the cavern roof was analyzed accordingly.
Dongsheng Xu, Chenxu Li, Chuantan Hou
wiley   +1 more source

Mathematical foundations of life, mind and all emergent phenomena. [PDF]

Front Syst Neurosci
Werbos PJ.
europepmc   +1 more source

Rock mechanical properties under reconstructed deep in situ thermo–hydro–mechanical conditions: Implications for CO₂‐related injection scenarios

Deep Underground Science and Engineering, EarlyView.
The graphical abstract illustrates a reconstructed in situ thermo‐hydro‐mechanical (THM) framework in which porosity serves as the central variable linking stress, pore pressure, and temperature to evolving mechanical properties of rocks. Under burial conditions, in situ stress, pore pressure, and temperature jointly govern volumetric strain and ...
Mingyuan Lu, Jun Wang, Zixiong Qi, Ruixuan Chen, Hongtao Wang, Hongwei Zhou   +5 more
wiley   +1 more source

Stochastic Rumor Propagation Dynamics with Log-Normal Ornstein-Uhlenbeck Process. [PDF]

Entropy (Basel)
Ablat N, Yu S, Jiang H.
europepmc   +1 more source