Results 121 to 130 of about 105,298 (255)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

The Nontriviality of Trivial General Covariance: How Electrons Restrict 'Time' Coordinates, Spinors (Almost) Fit into Tensor Calculus, and 7/16 of a Tetrad Is Surplus Structure [PDF]

, 2011
It is a commonplace in the philosophy of physics that any local physical theory can be represented using arbitrary coordinates, simply by using tensor calculus. On the other hand, the physics literature often claims that spinors \emph{as such} cannot be
Pitts, J. Brian, J. Brian Pitts
core  

Environmental controls on water‑carbon fluxes in winter wheat cropland under different hydrological and extreme environmental conditions in a dry semi-humid region

Ecological Indicators
The intensifying effects of climate change highlight the significance of understanding water–carbon fluxes in agroecosystems. Water use efficiency (WUE) is defined as the ratio of gross primary productivity (GPP) to evapotranspiration (ET), and it is a ...
Xuanang Liu, Yao Li, Xiaoyan Xu, Xiongbiao Peng, Xiaobo Gu, Lianyu Yu, Jiatun Xu, Huanjie Cai   +7 more
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A Comparison of Parametric Optimisation Techniques for Musical Instrument Tone Matching [PDF]

, 2011
Parametric optimisation techniques are compared in their abilities to elicit parameter settings for sound synthesis algorithms which cause them to emit sounds as similar as possible to target sounds.
Roth, Martin, Yee-King, Matthew
core  

A STUDY OF THE ROLE OF ARTIFICIAL INTELLIGENCE IN SHAPING HUMAN-ALGORITHMIC INTERACTIONS

Соціально-економічні відносини в цифровому суспільстві
This study examines the role of AI in shaping human-algorithm interaction (HAI) and determining its structural position within communication networks. The theoretical and methodological basis of the study includes social network analysis (SNA) and the ...
Anna Shalomova, Iryna Ignatieva
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Low-latency six-channel Bi-LSTM for near-real-time epileptic seizure detection

Discover Artificial Intelligence
This paper proposes a deep learning framework for near-real-time epileptic seizure detection using EEG data, designed to address two critical limitations of existing approaches: high detection latency and full-channel EEG dependence.
Kiyan Afsari, May El Barachi, Christian Ritz, Abigail Copiaco, Stefano Fasciani   +4 more
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source