Results 111 to 120 of about 105,298 (255)

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Protecting wild populations and working landscapes: the case for transitioning to size-based criteria for federal regulation of American ginseng

Environmental Research Letters
Overharvesting of wild medicinal plants threatens biodiversity, rural livelihoods, and the long-term sustainability of harvested populations worldwide.
Karam C Sheban, Nat S Burr, Anna K Plattner, Marlyse C Duguid, Alex C McAlvay, Mark A Bradford   +5 more
doaj   +1 more source

Surrogate-assisted optimization of orientation distribution functions for alloy 6061 using physics-based data and explainable machine learningGitHub

Next Materials
The crystallographic orientation distribution function (ODF) plays a significant role in controlling the anisotropic mechanical response of aluminum alloy 6061. However, optimization of high-dimensional ODFs still remains a challenge due to the nonlinear
Shakib Al Sharif
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Retrieval over Response: Large Language Model-Augmented Decision Strategies for Hierarchical Wildfire Risk Evaluation

Fire
The Analytic Hierarchy Process (AHP) is widely used in Multi-Criteria Decision Analysis (MCDA), yet its strong reliance on expert judgment constrains its scalability and may introduce variability in weighting outcomes, particularly in high-stakes ...
Yuheng Cheng, Yuchen Lin, Yanwei Wu, Lida Huang, Tao Chen, Wenguo Weng, Xiaole Zhang   +6 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Meta-learning for few-shot open task recognition

Scientific Reports
Current few-shot learning research often assumes predefined task configurations and evaluates under fixed N-way K-shot settings. In realistic deployments, the target configuration is unknown at training time, and both way and shot can differ from the ...
Xiaoming Han, Dianxi Shi, Zhen Wang, Yang Chen, Songchang Jin, Shaowu Yang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source