Results 91 to 100 of about 105,298 (255)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Exploring the stability of ultra-compact anisotropic dark energy stars with maximum allowable mass in $$R+\chi (R^{2}+\eta R^{3})$$ R + χ ( R 2 + η R 3 ) gravity

European Physical Journal C: Particles and Fields
In recent years, the modeling of compact astrophysical objects (COs) has garnered significant attention from various research groups, particularly in efforts to determine their stable structures.
Hammad Nazar, Ghulam Abbas, M. R. Shahzad, Asifa Ashraf, Ali H. Hakami, Ali M. Mubaraki   +5 more
doaj   +1 more source

PhonoMetric: a dual-metric engine for real-time English language accent evaluation and personalized speech training for Indian learners

Frontiers in Communication
The core objective of this study is to develop a novel method to measure and improve standard spoken English pronunciation accuracy in relation to a desired accent style using current speech processing and information retrieval methods.
Rajkumaran Soundarraj, Shenbagarajan Anantharajan, Saranraj Loganathan   +2 more
doaj   +1 more source

Asthma 101 for Schools: Successes and Challenges in Transitioning to Online Delivery

Frontiers in Public Health, 2016
Florida Asthma Program (FAP) staff worked with evaluators from the Florida State University College of Medicine (FSU) to assess participation and quality of the American Lung Association’s (ALA) Asthma 101 asthma management education program for school ...
Alexandra Catherine Hayes Nowakowski, Henry Joseph Carretta, Julie Kurlfink Dudley, Jamie R Forrest   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Formal software measurements for object-oriented business models [PDF]

, 1996
This paper presents a set of metrics and pseudo-metrics for the measurement of conceptual distances in M.E.R.O.D.E. business models. The measures are developed and validated using measure and measurement theory.
Dedene, Guido, Poels, Geert
core   +1 more source

On the problem of small motions and normal oscillations of a viscous fluid in a partially filled container [PDF]

, 2003
The famous classical S. Krein problem of small motions and normal oscillations of a viscous fluid in a partially filled container is investigated by a new approach based on a recently developed theory of operator matrices with unbounded entries.
Mennicken, Reinhard, Kopachevsky, Nikolay D., Azizov, Tomas Ya., Hardt, Volker   +3 more
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source