Results 71 to 80 of about 105,298 (255)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

“Zwitterionic Proton Sponge” Hydrogen Bonding Investigations on the Basis of Car–Parrinello Molecular Dynamics [PDF]

, 2015
1,8-Bis­(dimethylamino)-4,5-dihydroxynaphthalene has been investigated on the basis of static DFT computations and Car–Parrinello molecular dynamics. The simulations were performed in the gas phase and in the solid state. The studied “zwitterionic proton
Aneta Jezierska (1580284), Jarosław J. Panek (1580287)   +1 more
core   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Towards the study of the metric properties of the new fuzzy spheres of Fiore and Pisacane [PDF]

, 2021
Noncommutative spaces are strong candidates for the description of the underlying quantum structure of spacetime, and in this document we can see them arise through the introduction of energy cut-offs in a quantum theory.
Puerto Galindo, Sebastian Camilo
core  

Magnetic Anomaly Detection Based on a Multi-Parameter-Constrained Mirror Dual-Branch Biased Monostable Stochastic Resonance System

Sensors
Magnetic anomaly detection is vulnerable to environmental noise and insufficient prior target information, making non-periodic anomaly signals difficult to detect at low-signal-to-noise-ratio (SNR) conditions. This paper proposes a detection method based
Rongxiang Xia, Mingxi Chen, Lizhi Hong, Zhiyuan Ai, Shaojie Ma   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Tone-Metric Analysis: A Novel Approach to the Study of Form and Performance in North German Baroque Organ Music [PDF]

, 2020
This dissertation studies the principles and applications of tone-metric analysis, a novel analytical approach based on the assumption that beat (or tactus) is a combinatorial set of strong and weak beats.
Andreoni, Federico
core   +1 more source

Structured learning of metric ensembles with application to person re-identification [PDF]

, 2016
Matching individuals across non-overlapping camera networks, known as person re-identification, is a fundamentally challenging problem due to the large visual appearance changes caused by variations of viewpoints, lighting, and occlusion.
Sakrapee Paisitkriangkrai, Lin Wu, Shen, C., Paisitkriangkrai, S., Anton van den Hengel, Chunhua Shen, Wu, L., van den Hengel, A.   +7 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source