Results 51 to 60 of about 105,298 (255)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier +11 more
wiley +1 more source
Strong Nonadditivity as a Key Structure−Activity Relationship Feature: Distinguishing Structural Changes from Assay Artifacts [PDF]
, 2015 : Nonadditivity in protein−ligand affinity data represents highly instructive structure−activity relationship (SAR) features that indicate structural changes and have the potential to guide rational drug design.
Klaus R. Liedl (1235931) +5 more
core +1 more source
Geometry-informed modeling and evaluation of coverage resilience in complex communication networks
Applied Network ScienceThe development of 5 G technology drives economic and societal advancement. However, the expanding scale and increasing topological complexity of communication networks pose challenges for modeling higher-order coverage dependencies and assessing network
Bingchen Dong, Zhenglin Liang
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi +9 more
wiley +1 more source
Markuschevich bases and duality theory [PDF]
, 1970 Several duality theorems concerning Schauder bases in locally convex spaces have analogues in the theory of Markuschevich bases. For example, a locally convex space with a Markuschevich basis is semireflexive iff the basis is shrinking and boundedly ...
William B. Johnson
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Meta-Analysis of Conductive and Strong Carbon Nanotube Materials. [PDF]
, 2021 A study of 1304 data points collated over 266 papers statistically evaluates the relationships between carbon nanotube (CNT) material characteristics, including: electrical, mechanical, and thermal properties; ampacity; density; purity; microstructure ...
core +2 more sources
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Ecological causes of morphological evolution in the three-spined stickleback [PDF]
, 2013 The central assumption of evolutionary theory is that natural selection drives the adaptation of populations to local environmental conditions, resulting in the evolution of adaptive phenotypes.
C. Smith (2247166) +14 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source