Results 81 to 90 of about 665,867 (231)

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

LogoXpertNet: a novel lightweight logo classification using deep learning

Scientific Reports
Logo classification is crucial in various applications, including brand monitoring, copyright protection, and digital forensics. Traditional computer vision techniques face significant limitations, particularly in handling scale variations, occlusions ...
Muhammad Tahir Mumtaz, Mohd Khalid Awang, Muhammad Usman Saeed, Shafiq Hussain, Dhouha Ben Noureddine, Yassine Daadaa   +5 more
doaj   +1 more source

Testing of Saline–Alkali Tolerance in Oat Germplasm Through Integrated Germination and Field Performance Assessments

Agronomy
Oats are an important grain-feeding crop with strong saline–alkali tolerance; however, the genetic mechanism of this tolerance is not clear, which hinders the development of oat varieties adapted to saline soils.
Biru Zhang, Junzhen Mi, Baoping Zhao, Zhongshan Xu, Xingyan Li, Jinghui Liu, Zhiqiang Yuan   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Health insurance coverage in Mexico: progress, inequalities and remaining challenges towards UHC2030

Health Research Policy and Systems
Background Universal health coverage (UHC) requires strong institutional capacity, equity-oriented policies, sustained political and financial commitment and public trust.
Edson Serván-Mori, Diego Cerecero-García, Sergio Meneses-Navarro, Thomas Hone, Alejandro Mohar-Betancourt, Octavio Gómez-Dantés   +5 more
doaj   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Study on the effects of hydrological connectivity on the dispersal and driving factors of macroinvertebrate communities

Scientific Reports
Dispersal is crucial for the distribution of macroinvertebrate populations and communities. However, research on the dispersal of macroinvertebrates after dam demolition remains limited. Studying the impact processes and driving factors of dam demolition
Yuhang Zhang, Baohang Zhang, Hongtao Wang, Zhe Liu, Min Zhang, Haiping Zhang, Xiaodong Qu   +6 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source