Results 121 to 130 of about 772,522 (267)
Precarious employment and occupational injuries in the digital age ‒ where should we go from here?
Scandinavian Journal of Work, Environment & Health, 2018 There is growing demand for a clearer understanding of whether precarious work is a social determinant of health (1‒5) and whether non-standard workers with less job security are more vulnerable to adverse safety and health outcomes.
Helen Marucci-Wellman
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Experimental study on fractures quantitative characterization of shale during uniaxial compression
Frontiers in Earth ScienceIntroductionFractures are crucial to the development of shale oil and gas because they operate as a seepage pathway. The key to ensuring effective development is the fractures strong connection.
Liping Zhao, Hongjian Zhu
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Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Türk Kültürü ve Hacı Bektaş Velî Araştırma Dergisi, 2018 Mahmud al-Kashgari’s Divanu Lügati’t-Türk is a unique study of the language, history and life of Turkish communities. This work is considered as a reference source for many branches of science by researchers working on dictionary science, while it is ...
Yermukhamet MARALBEK, Muhammet KOÇAK
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Future InternetLung cancer (LC) remains a leading cause of cancer mortality worldwide, where accurate and early identification of gene mutations such as epidermal growth factor receptor (EGFR) is critical for precision treatment.
Muhammad Asif Munir +7 more
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
npj Climate and Atmospheric ScienceAtmospheric soot and organic particles from fossil fuel combustion and biomass burning modify Earth’s climate through their interactions with solar radiation and through modifications of cloud properties by acting as cloud condensation nuclei and ice ...
Weijun Li +8 more
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Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source