Results 101 to 110 of about 423,616 (265)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A Safety and Security-Centered Evaluation Framework for Large Language Models via Multi-Model Judgment

Mathematics
The pervasive deployment of large language models (LLMs) has given rise to mounting concerns regarding the safety and security of the content generated by these models.
Jinxin Zhang, Yunhao Xia, Hong Zhong, Weichen Lu, Qingwei Deng, Changsheng Wan   +5 more
doaj   +1 more source

On Distance and Strong Metric Dimension of the Modular Product

Bulletin of the Malaysian Mathematical Sciences Society
Comment: 24 pages, 1 figure, 27 ...
Cong X. Kang, Aleksander Kelenc, Iztok Peterin, Eunjeong Yi   +3 more
openaire   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Power Quality Transient Disturbance Diagnosis Based on Dynamic Large Convolution Kernel and Multi-Level Feature Fusion Network

Energies
Power quality is an important metric for the normal operation of a power system, and the accurate identification of transient signals is of great significance for the improvement of power quality.
Chen Zheng, Qionglin Li, Shuming Liu, Shuangyin Dai, Bo Zhang, Yajuan Liu   +5 more
doaj   +1 more source

The strong metric dimension of generalized Sierpiński graphs with pendant vertices

Ars Mathematica Contemporanea, 2016
Summary: Let \(G\) be a connected graph of order \(n\) having \(\varepsilon(G)\) end-vertices. Given a positive integer \(t\), we denote by \(S(G, t)\) the \(t\)-th generalized Sierpiński graph of \(G\). In this note we show that if every internal vertex of \(G\) is a cut vertex, then the strong metric dimension of \(S(G, t)\) is given by \[ \dim_s(S(G,
Estaji, Ehsan, Rodríguez-Velázquez, Juan Alberto   +1 more
openaire   +4 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Comparing Two Novel LiDAR‐Based Indices for Quantifying Forest Structural Complexity

Ecology and Evolution
Forest structural complexity is critical for ecosystem functions, yet standardized metrics for its quantification remain elusive. This study compares two LiDAR‐derived three‐dimensional indices, the box dimension (Db) as a fractal‐based measure, and ...
Tillman Reuter, Sebastian Seidel, Dominik Seidel   +2 more
doaj   +1 more source

Metric and strong metric dimension in TI-power graphs of finite groups

AIMS Mathematics
<p>Given a finite group $ G $ with the identity $ e $, the TI-power graph (trivial intersection power graph) of $ G $ is an undirected graph with vertex set $ G $, in which two distinct vertices $ x $ and $ y $ are adjacent if $ \langle x\rangle\cap \langle y\rangle = \{e\} $.
Chunqiang Cui, Jin Chen, Shixun Lin
openaire   +2 more sources