Results 81 to 90 of about 423,616 (265)
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Self-organized Emergence of Navigability on Small-World Networks
, 2010 This paper mainly investigates why small-world networks are navigable and how to navigate small-world networks. We find that the navigability can naturally emerge from self-organization in the absence of prior knowledge about underlying reference frames ...
Abraham I +20 more
core +1 more source
On the Strong Metric Dimension of directed co-graphs
, 2021 Let $G$ be a strongly connected directed graph and $u,v,w\in V(G)$ be three vertices. Then $w$ strongly resolves $u$ to $v$ if there is a shortest $u$-$w$-path containing $v$ or a shortest $w$-$v$-path containing $u$. A set $R\subseteq V(G)$ of vertices is a strong resolving set for a directed graph $G$ if for every pair of vertices $u,v\in V(G)$ there
Schmitz, Yannick, Wanke, Egon
openaire +2 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Confinement from distance in metric space and its relation to cosmological constant
Journal of High Energy PhysicsWe argue that, in a theory of quantum gravity, the gauge coupling and the confinement scale of a gauge theory are related to distance in the space of metric configurations, and in turn to the cosmological constant. To support the argument, we compute the
Amineh Mohseni, Mahdi Torabian
doaj +1 more source
Convergence-Driven Adaptive Many-Objective Particle Swarm Optimization
IEEE AccessIn recent years, the prevalence of Many-Objective Optimization Problems (MaOPs) in practical applications has been increasing. However, traditional multi-objective optimization algorithms, such as Multiple Objective Particle Swarm Optimization (MOPSO ...
Yunfei Yi +4 more
doaj +1 more source
The strong metric dimension of some generalized Petersen graphs
Applicable Analysis and Discrete Mathematics, 2017 In this paper the strong metric dimension of generalized Petersen graphs GP(n, 2) is considered. The exact value is determined for the cases n = 4k and n = 4k + 2, while for n = 4k + 1 an upper bound of the strong metric dimension is presented.
Kratica, Jozef +2 more
openaire +4 more sources