Results 91 to 100 of about 48,502 (244)

A Safety and Security-Centered Evaluation Framework for Large Language Models via Multi-Model Judgment

Mathematics
The pervasive deployment of large language models (LLMs) has given rise to mounting concerns regarding the safety and security of the content generated by these models.
Jinxin Zhang, Yunhao Xia, Hong Zhong, Weichen Lu, Qingwei Deng, Changsheng Wan   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Power Quality Transient Disturbance Diagnosis Based on Dynamic Large Convolution Kernel and Multi-Level Feature Fusion Network

Energies
Power quality is an important metric for the normal operation of a power system, and the accurate identification of transient signals is of great significance for the improvement of power quality.
Chen Zheng, Qionglin Li, Shuming Liu, Shuangyin Dai, Bo Zhang, Yajuan Liu   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The simultaneous (strong) metric dimension of graph families

, 2016
En aquesta tesi vam introduir la noció de resolubilitat simultània per a famílies de grafs definides sobre un conjunt de vèrtexs en comú. Els principals resultats de la tesi s'han abordat als generadors i bases mètrics simultanis, així com la dimensió mètrica simultània d'aquestes famílies.
openaire   +3 more sources

Symbioliving for sustainable development: theoretical design of an empathy index for companionship with the socially and environmentally vulnerable

Journal of Asian Architecture and Building Engineering
This study proposes the Integrated Empathy Index (IEI), a framework for assessing and fostering civic empathy toward social and environmental vulnerability.
Yeunsook Lee
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Manipulating chiral photon generation from plasmonic nanocavity-emitter hybrid systems: from weak to strong coupling

Nanophotonics
By confining light into a deep subwavelength scale to match the characteristic dimension of quantum emitters, plasmonic nanocavities can effectively imprint the light emission with unique properties in terms of intensity, directionality, as well as ...
Yang Jian, Hu Huatian, Zhang Qingfeng, Zu Shuai, Chen Wen, Xu Hongxing   +5 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source