Results 101 to 110 of about 1,913,798 (294)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

A Compatible Baseline Correction Algorithm for Strong-Motion Data

open access: yesTerrestrial, Atmospheric and Oceanic Sciences, 2012
In physics, acceleration, velocity, and displacement should be convertible with each other. However, many strong-motion data do not meet this requirement; the double integration of a disseminated acceleration might not be the same as the corresponding ...
Hung-Chie Chiu
doaj   +1 more source

INGV strong-motion data web-portal: a focus on the Emilia seismic sequence of May-June 2012

open access: yesAnnals of Geophysics, 2012
[…] Recently, an INGV working group developed the first version of a web portal with the aim of archiving, processing and distributing accelerometric data recorded by permanent and temporary INGV stations.
Marco Massa   +9 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

open access: yesFEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao   +3 more
wiley   +1 more source

Validation of strong-motion stochastic model using observed ground motion records in north-east India

open access: yesGeomatics, Natural Hazards & Risk, 2016
We focused on validation of applicability of semi-empirical technique (spectral models and stochastic simulation) for the estimation of ground-motion characteristics in the northeastern region (NER) of India.
Dipok K. Bora   +2 more
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Deep-Learning-Based Strong Ground Motion Signal Prediction in Real Time

open access: yesBuildings
Processing ground motion signals at early stages can be advantageous for issuing public warnings, deploying first-responder teams, and other time-sensitive measures.
Mohammad AlHamaydeh   +2 more
doaj   +1 more source

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