Results 101 to 110 of about 4,363,442 (260)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Strong products ofϰ-critical graphs [PDF]

open access: yesAequationes Mathematicae, 1993
LetG[H] be the lexicographic product and letG ⊠H be the strong product of the graphsG andH. It is proved that, ifG is aϰ-critical graph, then, for any graphH, $$\chi (G[H]) \leqslant \chi (H)(\chi (G) - 1) + \left[ {\frac{{\chi (H)}}{{\alpha (G)}}} \right ...
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

A Sharp Lower Bound For The Generalized 3-Edge-Connectivity Of Strong Product Graphs

open access: yesDiscussiones Mathematicae Graph Theory, 2017
The generalized k-connectivity κk(G) of a graph G, mentioned by Hager in 1985, is a natural generalization of the path-version of the classical connectivity. As a natural counterpart of this concept, Li et al.
Sun Yuefang
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

On Strong Bounds for Trotter and Zeno Product Formulas with Bosonic Applications [PDF]

open access: yesQuantum
The Trotter product formula and the quantum Zeno effect are both indispensable tools for constructing time-evolutions using experimentally feasible building blocks. In this work, we discuss assumptions under which quantitative bounds can be proven in the
Tim Möbus
doaj   +1 more source

Strong products of Kneser graphs

open access: yesDiscrete Mathematics, 1994
For a (simple, undirected) graph \(G = (V(G), E(G))\), let \(\chi(G)\) and \(\omega(G)\) denote the chromatic number and the clique number, respectively. A subgraph \(H\) of \(G\) is a retract of \(G\) iff there is an edge-preserving map \(h : V(G) \to V(H)\) with \(h(x) = x\) for all \(x \in V(H)\).
Klavžar, Sandi, Milutinović, Uroš
openaire   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Restricted Edge-Connectivity of Strong Product Graphs

open access: yesAxioms
The restricted edge-connectivity of a connected graph G, denoted by λ′(G), if it exists, is the minimum cardinality of a set of edges whose deletion makes G disconnected, and each component has at least two vertices.
Hazhe Ye, Yingzhi Tian
doaj   +1 more source

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