Results 171 to 180 of about 4,376,990 (279)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Preparation and Performance Study of Carboxylated Nitrile Rubber Based on Phase Transfer Catalysis: Screening of Optimal Catalyst System. [PDF]

Polymers (Basel)
Zheng H, Yue D.
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Estriol Is Likely Not Associated With Mouth Ulcerations in Pharmacovigilance Data. [PDF]

Int Dent J
Böhm R, Herdegen T.
europepmc   +1 more source

Particle production in strong interactions

, 1965
Imperial Users ...
King, Ronald Curtis, King, Ronald Curtis
openaire   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Exploring neuromarketing's influence on consumer impulsivity through the lens of personality traits. [PDF]

Front Psychol
Nagpal K, Bala K, Singh S, Yadav A, Paliwal M.   +4 more
europepmc   +1 more source

Strong Regulation of Medical Products: [PDF]

ADB Briefs, 2018
Jane Parry, Valerio Reggi, Douglas Ball, Sonalini Khetrapal, Susann Roth   +4 more
openaire   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Efficient selective hydrogenation of <i>N</i>,<i>N</i>-dimethylaniline in a continuous fixed-bed reactor over a Cu/Ni-Al₂O₃ catalyst. [PDF]

RSC Adv
Nong J, Sun Z, Zhou W, Wu Z, Qian J, Chen Q, He M.   +6 more
europepmc   +1 more source