Results 111 to 120 of about 10,261,192 (285)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Strong Stability for a Viscoelastic Transmission Problem Under a Nonlocal Boundary Control

Axioms
The purpose of this paper is to consider a transmission problem of a viscoelastic wave with nonlocal boundary control. It should be noted that the present paper is based on the previous C. G. Gal and M. Warma works, together with H. Atoui and A. Benaissa.
Noureddine Touati Brahim, Abderrahmane Beniani, Abderrazak Chaoui, Zayd Hajjej, Perikles Papadopoulos, Khaled Zennir   +5 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Stability and instability of Kirchhoff plate equations with delay on the boundary control

Electronic Journal of Differential Equations, 2023
Haidar Badawi, Mohammad Akil, Zayd Hajjej   +2 more
doaj  

The response characteristics and stability evaluation of vegetated slope under strong wind

Scientific Reports
As one of the major geological disasters in southeastern China, typhoon-induced vegetation slope instability causes significant loss of life and property each year. Despite the criticality of this issue, the response mechanism of vegetated slopes to wind
Yanlin Liu, Fei Wang, Feng Ji, Lianhua Zhang, Jianjun Zhao, Chen Zheng, Jibin Chen   +6 more
doaj   +1 more source

Enhanced Stability in Li-Rich Cathodes via Strong Nb4d-O2p Configurations and Li3PO4 Coating

Energy Material Advances
Lithium-rich layered oxides (LLOs) are considered promising cathode candidates for high-energy-density lithium-ion batteries. However, poor cycle stability and limited rate performance severely hinder their practical application.
Cuifeng Wang, Zhanshuo Liang, Haoxiang Zhuo, Guohua Li, Zhenyao Wang, Lihao Guo, Zhihao Jin, Haolin Liu, Jianlong Qin, Zhimin Ren, Xiaopeng Qi, Xueliang Sun, Jiantao Wang   +12 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source