Results 81 to 90 of about 95,473 (252)

Verification of the Storage Stability of Fecal Hemoglobin in Stool Sampling Bottle Using Improved Buffer - A Pilot Study -

Journal of the Anus, Rectum and Colon
Objective: The temperature and duration of sample storage is known to affect the accuracy of the fecal immunochemical test (FIT). This study compared an improved stool collection buffer with the conventional buffer on the fecal hemoglobin (Hb ...
Masakatsu Fukuzawa, Sakiko Naito, Shin Kono, Yoshiya Yamauchi, Takashi Morise, Kumiko Uchida, Yasuyuki Kagawa, Takahiro Muramatsu, Shiori Enomoto, Shizuka Takehara, Norimitsu Hosaka, Takao Itoi   +11 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Soy protein isolate-pectin from Nicandra Physaloides (Linn.) Gaertn seeds nanogels: A hydrocolloid system for blueberry preservation

Food Chemistry: X
Resveratrol (Res) and Phloretin (Pht) are natural compounds with antioxidant and anti-inflammatory activities, yet their practical applications face certain limitations.
Dan Meng, Wenqi Yang, Zhong Zhang, Xiaoyu Wang, Jianke Li, Li Yuan   +5 more
doaj   +1 more source

Strong Stability Preserving Multistep Runge-Kutta Methods

, 2013
High-order spatial discretizations with strong stability properties (such as monotonicity) are desirable for the solution of hyperbolic PDEs. Methods may be compared in terms of the strong stability preserving (SSP) time-step. We prove an upper bound on the SSP coefficient of explicit multistep Runge--Kutta methods of order two and above.
Bresten, Christopher, Gottlieb, Sigal, Grant, Zachary, Higgs, Daniel, Ketcheson, David I., Németh, Adrian   +5 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Substitutional Tb Incorporation, p–n Conductivity Transition, and Gamma-Irradiation Effects on the Thermoelectric Properties TbₓSn₁₋ₓSe Solid Solutions

East European Journal of Physics
The physicochemical and thermoelectric properties of TbₓSn₁₋ₓSe (0 ≤ x ≤ 0.05) solid solutions were systematically investigated with emphasis on composition-driven carrier-type transition and γ-irradiation effects. Differential thermal analysis reveals a
T.A. Jafarov, A.M. Allahverdiyev, G.A. Garashova, Kh.A. Adgezalova, O.M. Gasanov, I.M. Mammadov, J.I. Huseynov, I.I. Abbasov, V.I. Hajiyeva   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Quasi One-Dimensional Model of Natural Draft Wet-Cooling Tower Flow, Heat and Mass Transfer

EPJ Web of Conferences, 2015
The article deals with the development of CFD (Computational Fluid Dynamics) model of natural draft wet-cooling tower flow, heat and mass transfer. The moist air flow is described by the system of conservation laws along with additional equations.
Hyhlík Tomáš
doaj   +1 more source