Results 91 to 100 of about 11,180,110 (256)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The spectral analysis of strongly interacting matter [PDF]

, 1991
Karsch F, Satz H. The spectral analysis of strongly interacting matter. Zeitschrift für Physik, C: Particles and Fields.
Karsch, Frithjof, Satz, Helmut, H. Satz, F. Karsch   +3 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Quantum Dynamics of Strongly Interacting Many-Body Systems

, 2019
Recent advances in coherent manipulation and control have led to new opportunities to study non-equilibrium dynamics in quantum many-body systems. Using a variety of experimental platforms ranging from cold atoms and ions to solid-state spin defects ...
Choi, Soonwon
core   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Reliability of Strongly Nonlinear Single Degree of Freedom Dynamic Systems by the Path Integration Method [PDF]

, 2008
This paper presents a first passage type reliability analysis of strongly nonlinear stochastic single-degree-of-freedom systems. Specifically, the systems considered are a dry friction system, a stiffness controlled system, an inertia controlled system ...
Yurchenko, Daniil, Naess, Arvid, Mo, Eirik   +2 more
core   +1 more source

Microwave photons emitted by fractionally charged quasiparticles

Nature Communications, 2019
One of the many intriguing possibilities in strongly interacting quantum systems is the formation of emergent excitations with fractional charges. Here the authors show how the high-frequency noise emitted by a dc-biased quantum point contact can be used
R. Bisognin, H. Bartolomei, M. Kumar, I. Safi, J.-M. Berroir, E. Bocquillon, B. Plaçais, A. Cavanna, U. Gennser, Y. Jin, G. Fève   +10 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Strongly interacting Rydberg atoms in synthetic dimensions with a magnetic flux

Nature Communications
Synthetic dimensions, wherein dynamics occurs in a set of internal states, have found great success in recent years in exploring topological effects in cold atoms and photonics. However, the phenomena thus far explored have largely been restricted to the
Tao Chen, Chenxi Huang, Ivan Velkovsky, Kaden R. A. Hazzard, Jacob P. Covey, Bryce Gadway   +5 more
doaj   +1 more source