Results 81 to 90 of about 11,838,591 (211)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Total Controllability of the Second Order Semi-Linear Differential Equation with Infinite Delay and Non-Instantaneous Impulses

open access: yesMathematical and Computational Applications, 2018
In this manuscript, a stronger concept of exact controllability called Total Controllability has been introduced. Sufficient conditions have been established for the total controllability of the proposed problem.
Dimplekumar N. Chalishajar   +1 more
doaj   +1 more source

Strongly θ-continuous mappings between bitopological ordered spaces [PDF]

open access: yesDelta Journal of Science, 2009
A.A. Nouh   +2 more
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Strongly Regular Graphs with Maximal Energy [PDF]

open access: yes
The energy of a graph is the sum of the absolute values of the eigenvalues of its adjacency matrix. Koolen and Moulton have proved that the energy of a graph on n vertices is at most n(1 + √n)/2, and that equality holds if and only if the graph is ...
Haemers, W.H.
core  

Total Positivity: an application to positive linear operators and to their limiting semigroups

open access: yesJournal of Numerical Analysis and Approximation Theory, 2007
Some shape-preserving properties of positive linear operators, involving higher order convexity and Lipschitz classes, are investigated from the point of view of weak Tchebycheff systems and total positivity in the sense of Karlin [8].
Antonio Attalienti, Ioan Raşa
doaj   +2 more sources

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

Strongly Regular Graphs with Parameters (4m4, 2m4 + m2, m4 + m2, m4 + m2) Exist for All m>1 [PDF]

open access: yes
Using results on Hadamard difference sets, we construct regular graphical Hadamard matrices of negative type of order 4m4 for every positive integer m. If m > 1, such a Hadamard matrix is equivalent to a strongly regular graph with parameters (4m4, 2m4 ...
Xiang, Q., Haemers, W.H.
core  

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