Results 141 to 150 of about 2,919,635 (295)
Strongly Regular Graphs from Weakly Regular Plateaued Functions
, 2019 This paper presents the first construction of strongly regular graphs and association schemes from weakly regular plateaued functions over the finite fields of odd characteristic.
Mesnager, Sihem, Sinak, Ahmet
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
On strongly regular graphs with μ≤2
, 2006 In this paper we prove that any strongly regular graph with μ=1 satisfies k⩾(λ+1)(λ+2) and any strongly regular graph with μ=2 is either a grid graph or satisfies k⩾12λ(λ+3).
Bagchi, Bhaskar
core +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
On strongly regular graphs with μ ≥ 2
, 2003 In this paper, we prove that any strongly regular graph with μ = 1 satisfies k ≥ (λ + 1)(λ + 2) and any strongly regular graph with μ = 2 is either a grid graph or satisfies k ≥ 1/2λ(λ + 3).
Bagchi, Bhaskar
core +1 more source
Al-Rafidain Journal of Computer Sciences and Mathematics, 2004 Nazar H. Shuker, Rani S. Younis
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Al-Rafidain Journal of Computer Sciences and Mathematics, 2008 Anas S. Youns AL-Mashhdanny +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source