Results 91 to 100 of about 2,911,408 (294)
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Hamiltonian Strongly Regular Graphs [PDF]
We give a sufficient condition for a distance-regular graph to be Hamiltonian. In particular, the Petersen graph is the only connected non-Hamiltonian strongly regular graph on fewer than 99 vertices.Distance-regular graphs;Hamilton cycles JEL ...
Brouwer, A.E., Haemers, W.H.
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Strongly Regular Graphs with Maximal Energy [PDF]
The energy of a graph is the sum of the absolute values of the eigenvalues of its adjacency matrix. Koolen and Moulton have proved that the energy of a graph on n vertices is at most n(1 + √n)/2, and that equality holds if and only if the graph is ...
Haemers, W.H.
core
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Switching for Small Strongly Regular Graphs
Australas. J Comb., 2020 21 pages; accepted version, 26 Tables, 1 ...
openaire +5 more sources
Strongly Regular Graphs with Parameters (4m4, 2m4 + m2, m4 + m2, m4 + m2) Exist for All m>1 [PDF]
Using results on Hadamard difference sets, we construct regular graphical Hadamard matrices of negative type of order 4m4 for every positive integer m. If m > 1, such a Hadamard matrix is equivalent to a strongly regular graph with parameters (4m4, 2m4 ...
Xiang, Q., Haemers, W.H.
core
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source