Results 111 to 120 of about 2,911,408 (294)
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Developments on Spectral Characterizations of Graphs [PDF]
In [E.R. van Dam and W.H. Haemers, Which graphs are determined by their spectrum?, Linear Algebra Appl. 373 (2003), 241-272] we gave a survey of answers to the question of which graphs are determined by the spectrum of some matrix associated to the graph.
Dam, E.R. van, Haemers, W.H.
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Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens
FEBS Open Bio, EarlyView.Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee +3 more
wiley +1 more source
Fixed point theorems for nonexpansive mappings on nonconvex sets in UCED Banach spaces
International Journal of Mathematics and Mathematical Sciences, 2002 It is shown that every asymptotically regular or λ-firmly nonexpansive mapping T:C→C has a fixed point whenever C is a finite union of nonempty weakly compact convex subsets of a Banach space X which is uniformly convex in every direction.
Wei-Shih Du +2 more
doaj +1 more source
Some Implications on Amorphic Association Schemes [PDF]
AMS classifications: 05E30, 05B20;amorphic association scheme;strongly regular graph;(negative) Latin square type;cyclotomic association scheme;strongly regular ...
Dam, E.R. van, Muzychuk, M.
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Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Transitive combinatorial structures invariant under some subgroups of S(6,2) and related codes
Atti della Accademia Peloritana dei Pericolanti : Classe di Scienze Fisiche, Matematiche e Naturali, 2018 In this paper we define combinatorial structures on the conjugacy classes of the maximal subgroups of the symplectic group S(6,2) under the action of two subgroups of S(6,2) isomorphic to U(3,3) or U(4,2).
Dean Crnković +2 more
doaj +1 more source
Strongly regular graphs induced by polarities of symmetric designs [PDF]
Graphs ...
Higman, D.G. +2 more
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