Results 51 to 60 of about 29,610 (306)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Roughness Evaluation of Burnished Topography with a Precise Definition of the S-L Surface
Applied Sciences, 2022 Studies of surface topography including processes of measurement and data analysis have an influence on the description of machined parts with their tribological performance.
Przemysław Podulka
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
On the locating matrix of a graph and its spectral analysis [PDF]
Computer Science Journal of Moldova, 2017 We introduce a new matrix representation for a graph by defining the locating matrix $\mathbf{Lo}(G)$ of $G$. We define the locating eigenvalues, the locating spectrum, and locating energy of the graph and we calculate them for some standard graphs.
H. N. Ramaswamy +2 more
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The lower bound for number of hexagons in strongly regular graphs with parameters $\lambda=1$ and $\mu=2$ [PDF]
E-Journal of Analysis and Applied MathematicsThe existence of $srg(99,14,1,2)$ has been a question of interest for several decades to the moment. In this paper, we consider the structural properties in general for the family of strongly regular graphs with parameters $\lambda =1$ and $\mu =2$.
Reimbay Reimbayev
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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Two Classes of Linear Codes From Weil Sums
IEEE Access, 2020 In this article, we consider two classes of $p$ -ary linear codes. This article is a generalization of the recent construction methods given by Jian, Lin and Feng (2019).
Hong Lu, Shudi Yang
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Ural Mathematical JournalWe consider antipodal graphs \(\Gamma\) of diameter 4 for which \(\Gamma_{1,2}\) is a strongly regular graph. A.A. Makhnev and D.V. Paduchikh noticed that, in this case, \(\Delta=\Gamma_{3,4}\) is a strongly regular graph without triangles.
Alexander A. Makhnev +2 more
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LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source