Results 61 to 70 of about 2,798,542 (296)

Complete Weight Enumerators of a Class of Linear Codes From Weil Sums

IEEE Access, 2020
By appropriately choosing a defining set, we define a class of linear codes and determine their complete weight enumerators and weight enumerators using Weil sums.
Shudi Yang
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Regular graphs with four eigenvalues [PDF]

We study the connected regular graphs with four distinct eigenvalues. Properties and feasibility conditions of the eigenvalues are found. Several examples, constructions and characterizations are given, as well as some uniqueness and nonexistence results.
Dam, E.R. van
core   +2 more sources

GRAPHS \(\Gamma\) OF DIAMETER 4 FOR WHICH \(\Gamma_{3,4}\) IS A STRONGLY REGULAR GRAPH WITH \(\mu=4,6\)

Ural Mathematical Journal
We consider antipodal graphs \(\Gamma\) of diameter 4 for which  \(\Gamma_{1,2}\) is a strongly regular graph. A.A. Makhnev and D.V. Paduchikh noticed that, in this case, \(\Delta=\Gamma_{3,4}\) is a strongly regular graph without triangles.
Alexander A. Makhnev, Mikhail P. Golubyatnikov, Konstantin S. Efimov   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The lower bound for number of hexagons in strongly regular graphs with parameters $\lambda=1$ and $\mu=2$ [PDF]

E-Journal of Analysis and Applied Mathematics
The existence of $srg(99,14,1,2)$ has been a question of interest for several decades to the moment. In this paper, we consider the structural properties in general for the family of strongly regular graphs with parameters $\lambda =1$ and $\mu =2$.
Reimbay Reimbayev
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Two Classes of Linear Codes From Weil Sums

IEEE Access, 2020
In this article, we consider two classes of $p$ -ary linear codes. This article is a generalization of the recent construction methods given by Jian, Lin and Feng (2019).
Hong Lu, Shudi Yang
doaj   +1 more source

On Strongly Regular Graphs withμ= 1

European Journal of Combinatorics, 2001
The paper looks at strongly regular graphs in which each pair of non-adjacent vertices has exactly one common neighbour. Relationships between the parameters of such graphs are explored as are some of the associated particle linear spaces and distance-regular graphs.
J. Deutsch, P. H. Fisher
openaire   +2 more sources

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source