Results 51 to 60 of about 286,497 (273)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Non-existence of quasi-symmetric designs having certain pseudo-geometric block graphs

open access: yesAKCE International Journal of Graphs and Combinatorics
The block graph of a quasi-symmetric design is strongly regular. It is a challenging problem to decide which strongly regular graphs are block graphs of quasi-symmetric designs.
Kusum S. Rajbhar, Rajendra M. Pawale
doaj   +1 more source

New Strongly Regular Graphs from Finite Geometries via Switching [PDF]

open access: yes, 2019
We show that the strongly regular graph on non-isotropic points of one type of the polar spaces of type $U(n, 2)$, $O(n, 3)$, $O(n, 5)$, $O^+(n, 3)$, and $O^-(n, 3)$ are not determined by its parameters for $n \geq 6$.
Ihringer, Ferdinand, Munemasa, Akihiro
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

The Cayley graph built upon the semigroup of left ideals of a ring

open access: yes上海师范大学学报. 自然科学版, 2014
We investigate the interaction between a ring R and the Cayley graph Cay(L(R)) of the semigroup of left ideals of R,as well as subdigraphs of this graph.Graph theoretic properties of these graphs are investigated,such as transitive closure,girth,radius ...
Aihua Li, Ralph P.Tucci
doaj   +1 more source

Strongly Regular Graphs as Laplacian Extremal Graphs [PDF]

open access: yes, 2014
The Laplacian spread of a graph is the difference between the largest eigenvalue and the second-smallest eigenvalue of the Laplacian matrix of the graph.
Lin, Fan-Hsuan, Weng, Chih-wen
core  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

Complete Weight Enumerators of a Class of Linear Codes From Weil Sums

open access: yesIEEE Access, 2020
By appropriately choosing a defining set, we define a class of linear codes and determine their complete weight enumerators and weight enumerators using Weil sums.
Shudi Yang
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

On the locating matrix of a graph and its spectral analysis [PDF]

open access: yesComputer Science Journal of Moldova, 2017
We introduce a new matrix representation for a graph by defining the locating matrix $\mathbf{Lo}(G)$ of $G$. We define the locating eigenvalues, the locating spectrum, and locating energy of the graph and we calculate them for some standard graphs.
H. N. Ramaswamy   +2 more
doaj  

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