Results 51 to 60 of about 2,798,542 (296)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Non-existence of quasi-symmetric designs having certain pseudo-geometric block graphs
AKCE International Journal of Graphs and CombinatoricsThe block graph of a quasi-symmetric design is strongly regular. It is a challenging problem to decide which strongly regular graphs are block graphs of quasi-symmetric designs.
Kusum S. Rajbhar, Rajendra M. Pawale
doaj +1 more source
Some new models for multiprocessor interconnection networks [PDF]
Yugoslav Journal of Operations Research, 2016 A multiprocessor system can be modeled by a graph G. The vertices of G correspond to processors while edges represent links between processors. To find suitable models for multiprocessor interconnection networks (briefly MINs), one can apply ...
Cvetković Dragoš +2 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
The Cayley graph built upon the semigroup of left ideals of a ring
上海师范大学学报. 自然科学版, 2014 We investigate the interaction between a ring R and the Cayley graph Cay(L(R)) of the semigroup of left ideals of R,as well as subdigraphs of this graph.Graph theoretic properties of these graphs are investigated,such as transitive closure,girth,radius ...
Aihua Li, Ralph P.Tucci
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
On the locating matrix of a graph and its spectral analysis [PDF]
Computer Science Journal of Moldova, 2017 We introduce a new matrix representation for a graph by defining the locating matrix $\mathbf{Lo}(G)$ of $G$. We define the locating eigenvalues, the locating spectrum, and locating energy of the graph and we calculate them for some standard graphs.
H. N. Ramaswamy +2 more
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