Results 41 to 50 of about 111,506 (251)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effects of acute cervical stretching on arterial wall elastic properties

Frontiers in Physiology, 2023
Purpose: Acute (immediate) or regular (mid- or long-term) stretching increases arterial compliance and reduces arterial stiffness. Stretching is widely known to induce arterial functional factor changes, but it is unclear whether stretching alters ...
Harumi Ikebe, Harumi Ikebe, Naoya Oi, Akitoshi Makino, Daisuke Kume, Minenori Ishido, Tomohiro Nakamura, Masato Nishiwaki   +7 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The automorphism group of a class of strongly regular graphs related to Q(6,q)

European Journal of Combinatorics, 2008
Let \(Q(6,q)\) be a nondegenerate parabolic polar space in \(PG(6,q)\). Define the following graph \(\Gamma(q)\): the vertices of \(\Gamma(q)\) are all non-degenerate elliptic quadrics \(Q^-(5,q)\subset Q(6,q)\) and two vertices are adjacent provided the corresponding elliptic quadrics intersect in a tangent 4-space, that is, a cone \(pQ^-(3,q ...
De Winter, Stefaan, Van Maldeghem, Hendrik   +1 more
openaire   +3 more sources

Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk

Scientific Reports, 2021
Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning.
Arun Kumar, Mohammad Ali, Ranjit Kumar, Mukesh Kumar, Prity Sagar, Ritu Kumari Pandey, Vivek Akhouri, Vikas Kumar, Gautam Anand, Pintoo Kumar Niraj, Rita Rani, Santosh Kumar, Dhruv Kumar, Akhouri Bishwapriya, Ashok Kumar Ghosh   +14 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

On Strongly - Regular Rings

مجلة ابحاث كلية التربية الاساسية
             In our study we examine  definition of strongly γ -regular rings and associates, investigate  interplay between strongly γ - regular rings and other reduced rings. We also study GP – injective modules, and discuss its relation with strongly
Luma Ahmed Khaleel, Beyda S. Abdullah
doaj   +1 more source

Transitivity of the εm-relation on (m-idempotent) hyperrings

Open Mathematics, 2018
On a general hyperring, there is a fundamental relation, denoted γ*, such that the quotient set is a classical ring. In a previous paper, the authors defined the relation εm on general hyperrings, proving that its transitive closure εm∗$\begin{array}{} \
Norouzi Morteza, Cristea Irina
doaj   +1 more source

The architecture of partisan debates: The online controversy on the no-deal Brexit.

PLoS ONE, 2022
We propose a framework to analyse partisan debates that involves extracting, classifying and exploring the latent argumentation structure and dynamics of online societal controversies.
Carlo Romano Marcello Alessandro Santagiustina, Massimo Warglien   +1 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source