Results 41 to 50 of about 105,061,129 (288)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Effects of acute cervical stretching on arterial wall elastic properties

Frontiers in Physiology, 2023
Purpose: Acute (immediate) or regular (mid- or long-term) stretching increases arterial compliance and reduces arterial stiffness. Stretching is widely known to induce arterial functional factor changes, but it is unclear whether stretching alters ...
Harumi Ikebe, Harumi Ikebe, Naoya Oi, Akitoshi Makino, Daisuke Kume, Minenori Ishido, Tomohiro Nakamura, Masato Nishiwaki   +7 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Arsenic exposure in Indo Gangetic plains of Bihar causing increased cancer risk

Scientific Reports, 2021
Reportedly, 300 million people worldwide are affected by the consumption of arsenic contaminated groundwater. India prominently figures amongst them and the state of Bihar has shown an upsurge in cases affected by arsenic poisoning.
Arun Kumar, Mohammad Ali, Ranjit Kumar, Mukesh Kumar, Prity Sagar, Ritu Kumari Pandey, Vivek Akhouri, Vikas Kumar, Gautam Anand, Pintoo Kumar Niraj, Rita Rani, Santosh Kumar, Dhruv Kumar, Akhouri Bishwapriya, Ashok Kumar Ghosh   +14 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Coefficients Of The Inverse Of Strongly Starlike Functions. [PDF]

, 2003
For the class of strongly starlike functions, sharp bounds on the first four coefficients of the inverse functions are determined. A sharp estimate for the Fekete-Szego coefficient functional is also obtained.
M. Ali, Roslhan
core   +1 more source

The architecture of partisan debates: The online controversy on the no-deal Brexit.

PLoS ONE, 2022
We propose a framework to analyse partisan debates that involves extracting, classifying and exploring the latent argumentation structure and dynamics of online societal controversies.
Carlo Romano Marcello Alessandro Santagiustina, Massimo Warglien   +1 more
doaj   +1 more source

On(strongly) regular relations on soft topological hypergroups

Filomat
In the first step, we determine some conditions for having a topological complete hypergroup by defining the geometric space obtained from each strongly regular relation. Then applying set theory, we introduce the concepts of ?soft geometric spaces,? ?soft topological hypergroups,? and ?(strongly) regular relations? on soft hypergroups.
Asieh Pourhaghani, Hamid Torabi
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source