Results 21 to 30 of about 13,562 (260)

VARIETAL DIVERSITY OF WINTER GARLIC CCORDING TO RADIONUCLIDES ACCUMULATION IN CONDITIONS OF THE NON-CHERNOZEM ZONE

Овощи России, 2015
The results of evaluation of 5 varieties and 16 accessions from the collection of winter garlic (Allium sativum L.) based on the level of accumulation of cesium-137 and strontium-90 in condition of the Moscow region are shown.
T. M. Seredin, A. V. Soldatenko, E. G. Dobrutskaya, A. F. Agafonov, L. I. Gerasimova   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

The effect of detailing the trabecular structure of bone phantoms on the assessment of the bone marrow dose from 89,90Sr

Радиационная гигиена, 2023
Today there exist two main approaches to developing computational phantoms for bone dosimetry. The first approach is based on a detailed description of the microarchitecture of the spongiosa filling the phantoms.
P. A. Sharagin, E. A. Shishkina, E. I. Tolstykh, M. O. Degteva   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Setup and Application of Luminescent Property Measuring System for Materials Excited by Radioactive Sources

Journal of Isotopes
Radio-luminescence from radioactive isotopes has important applications in special fields. To accurately measure the luminescence characteristics of luminescent materials in specific light-emitting directions under radioactive source excitation，a ...
Yuqing YANG, Yisong LEI, Yebing LIU, Xiaoling XIONG, Gang LI, Shuming PENG   +5 more
doaj   +1 more source

ASSESSMENT OF COLLECTION NURSERY OF LEEK (ALLIUM PORRUM L.) FOR SELECTION ON STEADILY LOW LEVEL OF ACCUMULATION OF RADIONUCLIDES

Овощи России, 2018
Studies were conducted in the Moscow region. The object of research is leek (Allium porrum L.). As a result of carrying out an experiment with ten grades of leek of domestic and foreign selection high-quality reaction on accumulation of radionuclides ...
T. M. Seredin, A. V. Soldatenko, E. V. Baranova, V. V. Shumilina   +3 more
doaj   +1 more source

Initial Strontium-90 concentrations in ocean sediment from the northern Marshall Islands

Journal of Radiation Research and Applied Sciences, 2022
The United States detonated 67 nuclear weapons in the Marshall Islands from 1946 to 1958. While there has been significant study of the aftereffects of these explosions over the decades that followed, few values of strontium-90 (90Sr) contamination have ...
Hart I.E. Rapaport, Ivana Nikolic-Hughes, Emlyn W. Hughes   +2 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source