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Use of Structural Alerts for Reactive Metabolites in the Application SpotRM
Chemical Research in ToxicologyReactive metabolite (RM) formation is widely accepted as playing a crucial role in causing idiosyncratic adverse drug reactions (IADRs), where the liver is most affected. An important goal of drug design is to avoid selection of drug candidates giving rise to RMs and therefore risk causing problems later on involving IADRs.
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Paper alert: Structural biology
Current Opinion in Structural Biology, 2001Máire Convery +18 more
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International Journal of Environmental Research and Public Health, 2021
Yue Wu, Huixiao Hong, Minjun Chen
exaly
Yue Wu, Huixiao Hong, Minjun Chen
exaly
The sulfonamide group as a structural alert: A distorted story?
Current opinion in drug discovery & development, 2008The sulfonamide group is widely used in medicinal chemistry and appears in many marketed drugs in a variety of forms. One class of drugs that contain this group has been termed the 'sulfonamide antibacterials'. These compounds are inhibitors of tetrahydropteroic acid synthetase.
Dennis A, Smith, Rhys M, Jones
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Physicochemical Properties and Structural Alerts
2018Lilia Fisk, Nigel Greene, Russ Naven
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