Results 131 to 140 of about 69,991 (228)

Tecovirimat-Related Substance: Characterization, Hirshfeld Analysis, Theoretical Study, In Silico Toxicity Assessment

Molecules
Crystal structures of 4-(trifluoromethyl)benzene-1-carbohydrazide (1), 4-(trifluoromethyl)-N’-{[4-(trifluoromethyl)phenyl]carbonyl}benzohydrazide (2) and (1R,2S,6R,7S,8S,10R)-4-({[4-(trifluoromethyl)phenyl]carbonyl}amino)-4-azatetracyclo [5.3.2.08,10.02 ...
Fengfeng Wang, Xiaowen Hu, Caiyu Zhang, Lin Luan, Zhengzheng Zhou, Yang Liu   +5 more
doaj   +1 more source

OBUSight: Clinically Aligned Generative AI for Ophthalmic Ultrasound Interpretation and Diagnosis

Advanced Science, EarlyView.
OBUSight, a clinically aligned generative AI model that jointly generates reports and predicts diseases through multimodal semantic alignment, was trained and validated on a large multicenter dataset. OBUSight outperformed eight state‐of‐the‐art models, provided clinically reliable reports, enhanced diagnostic efficiency, and achieved performance ...
Xiaocong Liu, An Shao, Bingtao Guan, Ziyao Luo, Weiyi Lai, Xiaoling Huang, Jun Liu, Jie Yan, Huimin Li, Xiangji Pan, Jiawei Wang, Zichang Su, Yih Chung Tham, Jie Yang, Haotian Lin, Juan Ye, Hongxia Xu, Jian Wu   +17 more
wiley   +1 more source

S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning

Advanced Science, EarlyView.
Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu, Penglei Wang, Gaoyuan Xu, Jitao Lu, Qinke Peng, Danyang Wu, Hequan Sun   +6 more
wiley   +1 more source

Leveraging tree-transformer VAE with fragment tokenization for high-performance large chemical model generation

Communications Chemistry
Molecular generation models, especially chemical language model (CLM) utilizing SMILES, a string representation of compounds, face limitations in handling large and complex compounds while maintaining structural accuracy.
Tensei Inukai, Aoi Yamato, Manato Akiyama, Yasubumi Sakakibara   +3 more
doaj   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Ammonia Gas Sensor Fabricated by Multifunctional ZnO/GO Nanocomposites for Long‐Term, Self‐Powered Monitoring

Advanced Science, EarlyView.
Zinc oxide/graphene oxide (ZnO/GO) nanocomposites serve as a gas‐sensitive film for ammonia sensing and as high‐performance electrode materials in supercapacitors, simultaneously. A wearable contact‐separated triboelectric nanogenerator is designed to directly drive the ZnO/GO nanocomposites‐based ammonia sensor.
Xingwei Wang, Likun Gong, Xiaohong Zhou
wiley   +1 more source

Modification Strategies of Carbon‐Based Electrodes From Structural Regulation to Multifunctional Integration

Advanced Science, EarlyView.
Tracing the evolution from structural regulation to multifunctional integration, this paper systematically analyzes modification strategies for carbon‐based electrodes. It evaluates how element doping, surface functionalization, and composite material design affect the electrode performance, and offers perspectives on future applications and challenges
Yunlei Wang, Shitao Dou, Yifan Wu, Mingguang Wang, Taibin Wu   +4 more
wiley   +1 more source

Naked‐Eye Visual Warning of ppmv‐Level Fault‐Free Humidity Upper Limit

Advanced Science, EarlyView.
In this study, based on the urgent need in many critical fields for ppmv‐level fault‐free humidity upper limit (ppmv‐FFHUL) monitoring, an innovative threshold gated humidity sensing technology was developed. It exhibits superior portability (as thin and light as paper) and highly economic feature (without auxiliary instruments at all), and can achieve
Xiaoyan Wei, Tianyou Qin, Siyu Wang, Sean Xiao‐An Zhang, Lan Sheng   +4 more
wiley   +1 more source

H⁺ Exchange‐Driven ppb‐Level and High‐Selective Formaldehyde Detection at Room Temperature for Environmental and Clinical Applications

Advanced Science, EarlyView.
This article presents an innovative room‐temperature formaldehyde sensor based on H⁺ exchange method, achieving ppb‐level detection limit and exceptional selectivity. The study highlights its practical potential for real‐time environmental monitoring and clinical diagnostic applications.
Lubing Cai, Mengyang Pang, Zhaosong Liu, Yanfei Li, Jiani Li, Zhaorui Zhang, Fengshuang Zheng, Chao Li, Ang Zheng, Xuemin Zhang   +9 more
wiley   +1 more source

A Programmable Nanoreactor Orchestrates Cascade of DNA Sensing to Amplify cGAS‐STING Activation for Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable nanoreactor was engineered for precise cGAS‐STING pathway activation in cancer immunotherapy. This strategy bridges targeted tumor DNA damage with DC immunomodulation, providing a translatable platform to unlock innate and adaptive antitumor immunity.
Shuang Liang, Yiwei Tian, Feiyu Zhao, Yue Han, Kongshuo Ma, Linna Hai, Kaiqing Yun, Yueyang Zhao, Siqi Zhang, Ziyi Zhang, Yuxuan Peng, Kuan Hu, Jing Zhong, Bai Xiang, Zhaohui Wang   +14 more
wiley   +1 more source