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Implementation of a Multidevice Telemonitoring Program for Home-Based Nursing Care in Quebec: Qualitative Report. [PDF]
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Structural alerts for estimating the carcinogenicity of pesticides and biocides
SAR and QSAR in Environmental Research, 2011More than 20 years ago, Ashby and Tennant showed the interest of structural alerts for the prediction of the carcinogenicity of chemicals. These structural alerts are functional groups or structural features of various sizes that are linked to the level of carcinogenicity of chemicals.
Enrico Mombelli, J Devillers
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Mutagenic potential and structural alerts of phytotoxins
Food and Chemical Toxicology, 2023Toxic plant-produced chemicals, so-called phytotoxins, constitute a category of natural compounds belonging to a diversity of chemical classes. Some of them (e.g., alkaloids, terpenes, saponins) are associated with high toxic potency, while for many of others no toxicological data is available. In this study, the mutagenic potential of 1586 phytotoxins,
Arianna Bassan +2 more
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Structural alerts for the identification of bioaccumulative compounds
Integrated Environmental Assessment and Management, 2018Abstract Legislators have included bioaccumulation in the evaluation of chemicals in the framework of the European Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH) regulation.
Valsecchi, C +3 more
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From Structural Alerts to Signature Fragment Alerts: A Case Study on Pyrrolizidine Alkaloids
Chemical Research in Toxicology, 2023Even though modeling is considered a valid alternative to mutagenicity testing for substances with known structures, it can be applied for mixtures only if all of the single chemical structures are identified. Within the present work, we investigate a new avenue to exploit computational toxicology for mixtures, such as plant-based food ingredients ...
Elena Lo Piparo +2 more
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Verification of the Structural Alerts for Michael Acceptors
Chemical Research in Toxicology, 2007A diverse series of polarized alpha,beta-unsaturated and related compounds were evaluated for reactivity with a spectrophotometric assay using the sulfhydryl group in the form of the cysteine residue of the tripeptide GSH as a model nucleophile. The reactive end point (RC 50) calculations were compared to previously described structural alerts based on
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Structural Alerts of Mutagens and Carcinogens
Current Computer Aided-Drug Design, 2006This paper summarizes the evidence on the Structural Alerts of mutagenicity and carcinogenicity. The Structural Alerts are molecular substructures or reactive groups that are related to the carcinogenic and mutagenic properties of the chemicals, and represent a sort of "codification" of a long series of studies aimed at highlighting the mechanisms of ...
Romualdo Benigni, Cecilia Bossa
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Brain structures and receptors involved in alertness
Sleep Medicine, 2005Transitions between sleep and wakefulness are regulated by complex neurobiological mechanisms, which ultimately can be delineated as oscillations between two opponent processes--one promoting sleep and the other promoting wakefulness. The suprachiasmatic nuclei (SCN) provide temporal organization to the sleep-wake cycle through arousal mechanisms that ...
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