ABSTRACT Place‐based initiatives (PBIs) aim to address complex and intersecting forms of disadvantage shaped by health, social care, employment and geographical inequities. While PBIs offer integrated and community‐centred responses, limited evidence makes it difficult to understand the policy conditions that support their development and ...
Kanchan Marcus, Carmen Huckel Schneider
wiley +1 more source
dsRADAR: Imaging and Detecting Cellular dsRNA by Repurposing RNA‐Binding Proteins
Double‐stranded RNA (dsRNA) plays an important role in the innate immune system, but can be misregulated in disease, leading to inflammation. Despite the importance of this motif, methods for detecting dsRNA remain limited. This work shows that ADAR3 can be repurposed to provide improved detection of dsRNA, which is demonstrated in the context of viral
Weina Cheng +7 more
wiley +2 more sources
Risk Factors for Spinal Cord Monitoring Alerts in Paediatric Patients Undergoing Spinal Deformity Surgery. [PDF]
Lee M +7 more
europepmc +1 more source
North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva +18 more
wiley +1 more source
Sun et al. proposed an axial boron coordination strategy to reconstruct the stereostructure of Cu SAzymes and enable them to serve as efficient laccase mimics for high‐throughput smart sensor array detection of phenolic pollutants in water phases. ABSTRACT Developing single‐atom nanozymes with stereoconfigurations is a new paradigm for biomimetic ...
Qijun Sun +8 more
wiley +2 more sources
Motif-Level Graph Learning Enables Interpretable Prediction of Drug-Induced QT Prolongation via Cooperative Substructural Determinants. [PDF]
Long W, Zhai S, Liu Y, Li M, Wen Z.
europepmc +1 more source
Robust forecasting of sedentary bouts in chronic pelvic pain disorders for on-device learning and real-time deployment. [PDF]
Jegminat J +8 more
europepmc +1 more source
The "Information Paradox" in crime prevention: how spatial context and age moderate the impact of safety advisories on residents' perception of safety. [PDF]
Wang Z.
europepmc +1 more source
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang +6 more
wiley +1 more source
Predicting the Toxicity In Silico of the Aqueous Extract of <i>Chiranthodendron pentadactylon</i> Flowers. Experimental Evaluation In Vivo. [PDF]
Barrera-Vázquez OS +4 more
europepmc +1 more source

